biostudies-literatureHuenges Wajer IMCNetherlands Heart Foundation1486-1489https://www.ebi.ac.uk/biostudies/studies/S-EPMC6282849biostudies-literatureUnknown25(12)<h4>Background and purpose</h4>In randomized trials magnesium supplementation did not improve clinical outcome after aneurysmal subarachnoid haemorrhage (aSAH) on handicap scales. After aSAH, many patients have cognitive problems that may not translate into handicap. The effect of magnesium on cognitive outcome after aSAH was studied.<h4>Methods</h4>In total, 209 patients who had been included in the Magnesium for Aneurysmal Subarachnoid Haemorrhage (MASH-2) trial in the University Medical Centre of Utrecht were studied. Patients had been randomized to 64 mmol magnesium sulfate daily or placebo during hospitalization. Three months after aSAH patients underwent a neuropsychological examination (NPE) consisting of six neuropsychological tests or a brief cognitive assessment. Poisson and lineEuropean journal of neurologyEffect of magnesium on cognition after aneurysmal subarachnoid haemorrhage in a randomized trial.PMC62828492005BO16Rinkel GJEHuenges Wajer IMCvan Zandvoort MJEDorhout Mees SMvan den Bergh WMAlgra AVisser-Meily JMAfalseEffect of magnesium on cognition after aneurysmal subarachnoid haemorrhage in a randomized trial.<h4>Background and purpose</h4>In randomized trials magnesium supplementation did not improve clinical outcome after aneurysmal subarachnoid haemorrhage (aSAH) on handicap scales. After aSAH, many patients have cognitive problems that may not translate into handicap. The effect of magnesium on cognitive outcome after aSAH was studied.<h4>Methods</h4>In total, 209 patients who had been included in the Magnesium for Aneurysmal Subarachnoid Haemorrhage (MASH-2) trial in the University Medical Centre of Utrecht were studied. Patients had been randomized to 64 mmol magnesium sulfate daily or placebo during hospitalization. Three months after aSAH patients underwent a neuropsychological examination (NPE) consisting of six neuropsychological tests or a brief cognitive assessment. Poisson and line2018-01-01T00:00:00Z2018 Dec2026-07-16T08:00:15.397Z2019-03-27T00:11:16ZS-EPMC62828493004802710.1111/ene.13764