biostudies-literatureUnknown97(48)Shuai T<h4>Background</h4>Oropharyngeal mucositis is considered to be an inevitable and the most troubling side effect of head and neck irradiation, which is caused by the direct toxic action of radiation on oral mucosa. Several randomized controlled trials (RCTs) have investigated the efficacy of zinc sulfate in prevention of radiation-induced oropharyngeal mucositis in patients with head and neck cancer. However, the definite conclusions have not been confirmed. The systematic review and meta-analysis will be performed to comprehensively evaluate whether zinc sulfate is effective in prevention of radiation-induced oropharyngeal mucositis in patients with head and neck cancer.<h4>Methods</h4>Relevant information will be identified by a comprehensive search of the following electronic databases: Medicinee13310https://www.ebi.ac.uk/biostudies/studies/S-EPMC6283232biostudies-literatureProphylaxis with oral zinc sulfate against radiation-induced oropharyngeal mucositis in patients with head and neck cancer: Protocol for a meta-analysis of randomized controlled trials.PMC6283232Tian XShuai TChen WQYi LJChen HLi XEfalseProphylaxis with oral zinc sulfate against radiation-induced oropharyngeal mucositis in patients with head and neck cancer: Protocol for a meta-analysis of randomized controlled trials.<h4>Background</h4>Oropharyngeal mucositis is considered to be an inevitable and the most troubling side effect of head and neck irradiation, which is caused by the direct toxic action of radiation on oral mucosa. Several randomized controlled trials (RCTs) have investigated the efficacy of zinc sulfate in prevention of radiation-induced oropharyngeal mucositis in patients with head and neck cancer. However, the definite conclusions have not been confirmed. The systematic review and meta-analysis will be performed to comprehensively evaluate whether zinc sulfate is effective in prevention of radiation-induced oropharyngeal mucositis in patients with head and neck cancer.<h4>Methods</h4>Relevant information will be identified by a comprehensive search of the following electronic databases: 2018-01-01T00:00:00Z2018 Nov2025-04-04T12:41:56.982Z2019-03-27T00:13:43ZS-EPMC62832323050892010.1097/MD.0000000000013310