{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Morales-Ortiz J"],"funding":["NHLBI NIH HHS","NIMHD NIH HHS","NIGMS NIH HHS"],"pagination":["2495-2505"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6284217"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["132(23)"],"pubmed_abstract":["Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) affect >200 000 individuals yearly with a 40% mortality rate. Although platelets are implicated in the progression of ALI/ARDS, their exact role remains undefined. Triggering receptor expressed in myeloid cells (TREM)-like transcript 1 (TLT-1) is found on platelets, binds fibrinogen, and mediates clot formation. We hypothesized that platelets use TLT-1 to manage the progression of ALI/ARDS. Here we retrospectively measure plasma levels of soluble TLT-1 (sTLT-1) from the ARDS Network clinical trial and show that patients whose sTLT-1 levels were >1200 pg/mL had nearly twice the mortality risk as those with <1200 pg/mL (<i>P</i> < .001). After correcting for confounding factors such as creatinine levels, Acute Physiology "],"journal":["Blood"],"pubmed_title":["Platelet-derived TLT-1 is a prognostic indicator in ALI/ARDS and prevents tissue damage in the lungs in a mouse model."],"pmcid":["PMC6284217"],"funding_grant_id":["SC2 GM081237","K01 GM103806","R01 HL090933","P20 GM103642","U54 MD007587","P20 GM103475"],"pubmed_authors":["Ortiz-Zuazaga H","Rowley JW","Deal V","John AS","Chen J","Madera B","Maldonado-Martinez G","Croft C","Hunter R","Morales-Ortiz J","Reyes F","Ledesma N","Pacheco A","Lopez J","Rondina MT","Gibson A","Yost CC","Staback F","Washington AV"],"additional_accession":[]},"is_claimable":false,"name":"Platelet-derived TLT-1 is a prognostic indicator in ALI/ARDS and prevents tissue damage in the lungs in a mouse model.","description":"Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) affect >200 000 individuals yearly with a 40% mortality rate. Although platelets are implicated in the progression of ALI/ARDS, their exact role remains undefined. Triggering receptor expressed in myeloid cells (TREM)-like transcript 1 (TLT-1) is found on platelets, binds fibrinogen, and mediates clot formation. We hypothesized that platelets use TLT-1 to manage the progression of ALI/ARDS. Here we retrospectively measure plasma levels of soluble TLT-1 (sTLT-1) from the ARDS Network clinical trial and show that patients whose sTLT-1 levels were >1200 pg/mL had nearly twice the mortality risk as those with <1200 pg/mL (<i>P</i> < .001). After correcting for confounding factors such as creatinine levels, Acute Physiology ","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Dec","modification":"2025-04-19T01:51:06.934Z","creation":"2021-02-20T20:03:56Z"},"accession":"S-EPMC6284217","cross_references":{"pubmed":["30282800"],"doi":["10.1182/blood-2018-03-841593"]}}