biostudies-literatureMorales-Ortiz JNHLBI NIH HHSNIMHD NIH HHSNIGMS NIH HHS2495-2505https://www.ebi.ac.uk/biostudies/studies/S-EPMC6284217biostudies-literatureUnknown132(23)Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) affect >200 000 individuals yearly with a 40% mortality rate. Although platelets are implicated in the progression of ALI/ARDS, their exact role remains undefined. Triggering receptor expressed in myeloid cells (TREM)-like transcript 1 (TLT-1) is found on platelets, binds fibrinogen, and mediates clot formation. We hypothesized that platelets use TLT-1 to manage the progression of ALI/ARDS. Here we retrospectively measure plasma levels of soluble TLT-1 (sTLT-1) from the ARDS Network clinical trial and show that patients whose sTLT-1 levels were >1200 pg/mL had nearly twice the mortality risk as those with <1200 pg/mL (<i>P</i> < .001). After correcting for confounding factors such as creatinine levels, Acute Physiology BloodPlatelet-derived TLT-1 is a prognostic indicator in ALI/ARDS and prevents tissue damage in the lungs in a mouse model.PMC6284217SC2 GM081237K01 GM103806R01 HL090933P20 GM103642U54 MD007587P20 GM103475Ortiz-Zuazaga HRowley JWDeal VJohn ASChen JMadera BMaldonado-Martinez GCroft CHunter RMorales-Ortiz JReyes FLedesma NPacheco ALopez JRondina MTGibson AYost CCStaback FWashington AVfalsePlatelet-derived TLT-1 is a prognostic indicator in ALI/ARDS and prevents tissue damage in the lungs in a mouse model.Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) affect >200 000 individuals yearly with a 40% mortality rate. Although platelets are implicated in the progression of ALI/ARDS, their exact role remains undefined. Triggering receptor expressed in myeloid cells (TREM)-like transcript 1 (TLT-1) is found on platelets, binds fibrinogen, and mediates clot formation. We hypothesized that platelets use TLT-1 to manage the progression of ALI/ARDS. Here we retrospectively measure plasma levels of soluble TLT-1 (sTLT-1) from the ARDS Network clinical trial and show that patients whose sTLT-1 levels were >1200 pg/mL had nearly twice the mortality risk as those with <1200 pg/mL (<i>P</i> < .001). After correcting for confounding factors such as creatinine levels, Acute Physiology 2018-01-01T00:00:00Z2018 Dec2025-04-19T01:51:06.934Z2021-02-20T20:03:56ZS-EPMC62842173028280010.1182/blood-2018-03-841593