{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lynch RM"],"funding":["NCATS NIH HHS","NIAID NIH HHS"],"pagination":["26-30"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6284544"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["219(1)"],"pubmed_abstract":["The role of neutralizing antibodies in Zika-induced Guillain-Barré syndrome (GBS) has not yet been investigated. We conducted a case-control study using sera from the 2016 Zika epidemic in Colombia to determine the neutralizing antibody activity against Zika virus (ZIKV) and dengue virus serotype 2 (DENV2). We observed increased neutralizing antibody titers against DENV2 in ZIKV-infected individuals compared with uninfected controls and higher titers to both ZIKV and DENV2 in ZIKV-infected patients diagnosed with GBS compared with non-GBS ZIKV-infected controls. These data suggest that high neutralizing antibody titers to DENV and to ZIKV are associated with GBS during ZIKV infection."],"journal":["The Journal of infectious diseases"],"pubmed_title":["Augmented Zika and Dengue Neutralizing Antibodies Are Associated With Guillain-Barre Syndrome."],"pmcid":["PMC6284544"],"funding_grant_id":["P01 AI106695","KL2 TR001877","UL1 TR001876"],"pubmed_authors":["Li G","Bethony JM","Simon GL","Lynch RM","Harris E","Chang AY","Mantus G","Pacheco N","Porras A","Rengifo-Pardo M","Mendoza AR","Encinales L","Peng J","Cruz MM"],"additional_accession":[]},"is_claimable":false,"name":"Augmented Zika and Dengue Neutralizing Antibodies Are Associated With Guillain-Barre Syndrome.","description":"The role of neutralizing antibodies in Zika-induced Guillain-Barré syndrome (GBS) has not yet been investigated. We conducted a case-control study using sera from the 2016 Zika epidemic in Colombia to determine the neutralizing antibody activity against Zika virus (ZIKV) and dengue virus serotype 2 (DENV2). We observed increased neutralizing antibody titers against DENV2 in ZIKV-infected individuals compared with uninfected controls and higher titers to both ZIKV and DENV2 in ZIKV-infected patients diagnosed with GBS compared with non-GBS ZIKV-infected controls. These data suggest that high neutralizing antibody titers to DENV and to ZIKV are associated with GBS during ZIKV infection.","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Jan","modification":"2025-04-26T03:00:41.704Z","creation":"2019-03-27T00:11:17Z"},"accession":"S-EPMC6284544","cross_references":{"pubmed":["30113672"],"doi":["10.1093/infdis/jiy466"]}}