biostudies-literatureLynch RMNCATS NIH HHSNIAID NIH HHS26-30https://www.ebi.ac.uk/biostudies/studies/S-EPMC6284544biostudies-literatureUnknown219(1)The role of neutralizing antibodies in Zika-induced Guillain-Barré syndrome (GBS) has not yet been investigated. We conducted a case-control study using sera from the 2016 Zika epidemic in Colombia to determine the neutralizing antibody activity against Zika virus (ZIKV) and dengue virus serotype 2 (DENV2). We observed increased neutralizing antibody titers against DENV2 in ZIKV-infected individuals compared with uninfected controls and higher titers to both ZIKV and DENV2 in ZIKV-infected patients diagnosed with GBS compared with non-GBS ZIKV-infected controls. These data suggest that high neutralizing antibody titers to DENV and to ZIKV are associated with GBS during ZIKV infection.The Journal of infectious diseasesAugmented Zika and Dengue Neutralizing Antibodies Are Associated With Guillain-Barre Syndrome.PMC6284544P01 AI106695KL2 TR001877UL1 TR001876Li GBethony JMSimon GLLynch RMHarris EChang AYMantus GPacheco NPorras ARengifo-Pardo MMendoza AREncinales LPeng JCruz MMfalseAugmented Zika and Dengue Neutralizing Antibodies Are Associated With Guillain-Barre Syndrome.The role of neutralizing antibodies in Zika-induced Guillain-Barré syndrome (GBS) has not yet been investigated. We conducted a case-control study using sera from the 2016 Zika epidemic in Colombia to determine the neutralizing antibody activity against Zika virus (ZIKV) and dengue virus serotype 2 (DENV2). We observed increased neutralizing antibody titers against DENV2 in ZIKV-infected individuals compared with uninfected controls and higher titers to both ZIKV and DENV2 in ZIKV-infected patients diagnosed with GBS compared with non-GBS ZIKV-infected controls. These data suggest that high neutralizing antibody titers to DENV and to ZIKV are associated with GBS during ZIKV infection.2019-01-01T00:00:00Z2019 Jan2025-04-26T03:00:41.704Z2019-03-27T00:11:17ZS-EPMC62845443011367210.1093/infdis/jiy466