biostudies-literatureKhan SSNCATS NIH HHSNIDDK NIH HHSKaiser Foundation Research InstituteNHLBI NIH HHSUniversity of Alabama at BirminghamNational Heart, Lung, and Blood InstituteNorthwestern UniversityUniversity of MinnesotaNational Institutes of HealthJohns Hopkins University School of Medicine1261-1269.e8https://www.ebi.ac.uk/biostudies/studies/S-EPMC6286208biostudies-literatureUnknown31(12)<h4>Background</h4>The aim of this study was to determine whether long-term patterns of change in adiposity throughout young adulthood are associated with systolic and diastolic function in midlife.<h4>Methods</h4>Participants in the Coronary Artery Risk Development in Young Adults study, a multicenter, population-based cohort, underwent repeated anthropometric assessment (body mass index [BMI], waist circumference, and waist-to-hip ratio) from examination years 0 to 25. At year 25, longitudinal, circumferential, and radial strain and tissue Doppler velocities were assessed by echocardiography. Group-based trajectory modeling was used to identify 25-year trajectories of change in anthropometric measures and to examine associations between trajectories of adiposity change and indices of carJournal of the American Society of Echocardiography : official publication of the American Society of EchocardiographyAssociation of Patterns of Change in Adiposity With Diastolic Function and Systolic Myocardial Mechanics From Early Adulthood to Middle Age: The Coronary Artery Risk Development in Young Adults Study.PMC6286208HHSN268200900041CHHSN268201300028CHHSN268201300027CKL2TR001424F32 HL129695P30 DK079626HHSN268201300029CHHSN268201300025CF32HL129695KL2 TR001424Panjwani ALewis CEKhan SSLiu KGoff DCReis JVasconcellos HDAllen NBLima JACColangelo LALloyd-Jones DShay CMShah SJfalseAssociation of Patterns of Change in Adiposity With Diastolic Function and Systolic Myocardial Mechanics From Early Adulthood to Middle Age: The Coronary Artery Risk Development in Young Adults Study.<h4>Background</h4>The aim of this study was to determine whether long-term patterns of change in adiposity throughout young adulthood are associated with systolic and diastolic function in midlife.<h4>Methods</h4>Participants in the Coronary Artery Risk Development in Young Adults study, a multicenter, population-based cohort, underwent repeated anthropometric assessment (body mass index [BMI], waist circumference, and waist-to-hip ratio) from examination years 0 to 25. At year 25, longitudinal, circumferential, and radial strain and tissue Doppler velocities were assessed by echocardiography. Group-based trajectory modeling was used to identify 25-year trajectories of change in anthropometric measures and to examine associations between trajectories of adiposity change and indices of car2018-01-01T00:00:00Z2018 Dec2025-04-04T01:57:49.49Z2020-10-29T14:39:39ZS-EPMC62862083018100810.1016/j.echo.2018.07.014