{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Jang S"],"funding":["NCRR NIH HHS","NIMHD NIH HHS","U.S. Department of Health & Human Services | NIH | National Center for Research Resources","U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences","NIGMS NIH HHS","U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS)","U.S. Department of Health & Human Services | NIH | National Center for Research Resources (NCRR)"],"pagination":["17732"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6286307"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["8(1)"],"pubmed_abstract":["Mitochondrial electron transport chain (ETC) plays a central role in ATP synthesis, and its dysfunction is associated with human diseases. Recent studies revealed that individual ETC complexes are assembled into supercomplexes. The main supercomplex, respirasome composed of complexes I, III, and IV has been suggested to improve electron channeling and control ROS production, maintain the structural integrity of ETC complexes and prevent protein aggregation in the inner mitochondrial membrane. However, many questions related to the structural organization of the respirasome, particularly, a possible role of complexes I and II in respirasome formation remain unclear. Here, we investigated whether genetic and pharmacological inhibition of complexes I and II affect respirasome assembly in card"],"journal":["Scientific reports"],"pubmed_title":["Elucidating the contribution of ETC complexes I and II to the respirasome formation in cardiac mitochondria."],"pmcid":["PMC6286307"],"funding_grant_id":["SC1GM128210","G12RR-003051","SC1 GM128210","G12 MD007600","G12 RR003051","G12MD007600"],"pubmed_authors":["Jang S","Javadov S"],"additional_accession":[]},"is_claimable":false,"name":"Elucidating the contribution of ETC complexes I and II to the respirasome formation in cardiac mitochondria.","description":"Mitochondrial electron transport chain (ETC) plays a central role in ATP synthesis, and its dysfunction is associated with human diseases. Recent studies revealed that individual ETC complexes are assembled into supercomplexes. The main supercomplex, respirasome composed of complexes I, III, and IV has been suggested to improve electron channeling and control ROS production, maintain the structural integrity of ETC complexes and prevent protein aggregation in the inner mitochondrial membrane. However, many questions related to the structural organization of the respirasome, particularly, a possible role of complexes I and II in respirasome formation remain unclear. Here, we investigated whether genetic and pharmacological inhibition of complexes I and II affect respirasome assembly in card","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Dec","modification":"2025-04-26T02:58:04.536Z","creation":"2019-03-27T00:12:50Z"},"accession":"S-EPMC6286307","cross_references":{"pubmed":["30531981"],"doi":["10.1038/s41598-018-36040-9"]}}