{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["25"],"submitter":["Schmautz C"],"funding":["Technische Universität München","Deutsche Forschungsgemeinschaft","Vereinigung zur Förderung der Milchwissenschaftlichen Forschung an der Technischen Universität München","Biosys UK Ltd."],"pubmed_abstract":["<h4>Background</h4>New treatment options are needed to prevent relapses following failed antibiotic therapies of <i>Clostridium difficile</i> infections (CDI) in humans. The concomitant therapy with an anti-<i>C. difficile</i> IgA containing whey protein concentrate can support the sustainable recovery of CDI patients. For 31 weeks, nine dairy cows were continuously vaccinated with several anti-<i>C. difficile</i> vaccines by certain routes of administration to produce anti-<i>C. difficile</i> IgA enriched milk. The study aimed at finding decisive differences between low responder (LR) and high responder (HR) cows (> 8.0 µg ml<sup>-1</sup> total milk <i>C. difficile</i> specific IgA) concerning their immune response to vaccination on cellular and molecular biological levels.<h4>Results</h4"],"journal":["Journal of biological research (Thessalonike, Greece)"],"pagination":["20"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6288880"],"repository":["biostudies-literature"],"pubmed_title":["Immune cell counts and signaling in body fluids of cows vaccinated against <i>Clostridium difficile</i>."],"pmcid":["PMC6288880"],"pubmed_authors":["Muller N","Auer M","Schmautz C","Ballweg I","Pfaffl MW","Kliem H"],"additional_accession":[]},"is_claimable":false,"name":"Immune cell counts and signaling in body fluids of cows vaccinated against <i>Clostridium difficile</i>.","description":"<h4>Background</h4>New treatment options are needed to prevent relapses following failed antibiotic therapies of <i>Clostridium difficile</i> infections (CDI) in humans. The concomitant therapy with an anti-<i>C. difficile</i> IgA containing whey protein concentrate can support the sustainable recovery of CDI patients. For 31 weeks, nine dairy cows were continuously vaccinated with several anti-<i>C. difficile</i> vaccines by certain routes of administration to produce anti-<i>C. difficile</i> IgA enriched milk. The study aimed at finding decisive differences between low responder (LR) and high responder (HR) cows (> 8.0 µg ml<sup>-1</sup> total milk <i>C. difficile</i> specific IgA) concerning their immune response to vaccination on cellular and molecular biological levels.<h4>Results</h4","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Dec","modification":"2026-05-05T22:23:32.617Z","creation":"2019-03-27T00:12:23Z"},"accession":"S-EPMC6288880","cross_references":{"pubmed":["30555805"],"doi":["10.1186/s40709-018-0092-4"]}}