biostudies-literatureUnknown25Schmautz CTechnische Universität MünchenDeutsche ForschungsgemeinschaftVereinigung zur Förderung der Milchwissenschaftlichen Forschung an der Technischen Universität MünchenBiosys UK Ltd.<h4>Background</h4>New treatment options are needed to prevent relapses following failed antibiotic therapies of <i>Clostridium difficile</i> infections (CDI) in humans. The concomitant therapy with an anti-<i>C. difficile</i> IgA containing whey protein concentrate can support the sustainable recovery of CDI patients. For 31 weeks, nine dairy cows were continuously vaccinated with several anti-<i>C. difficile</i> vaccines by certain routes of administration to produce anti-<i>C. difficile</i> IgA enriched milk. The study aimed at finding decisive differences between low responder (LR) and high responder (HR) cows (> 8.0 µg ml^-1 total milk <i>C. difficile</i> specific IgA) concerning their immune response to vaccination on cellular and molecular biological levels.<h4>Results</h4Journal of biological research (Thessalonike, Greece)20https://www.ebi.ac.uk/biostudies/studies/S-EPMC6288880biostudies-literatureImmune cell counts and signaling in body fluids of cows vaccinated against <i>Clostridium difficile</i>.PMC6288880Muller NAuer MSchmautz CBallweg IPfaffl MWKliem HfalseImmune cell counts and signaling in body fluids of cows vaccinated against <i>Clostridium difficile</i>.<h4>Background</h4>New treatment options are needed to prevent relapses following failed antibiotic therapies of <i>Clostridium difficile</i> infections (CDI) in humans. The concomitant therapy with an anti-<i>C. difficile</i> IgA containing whey protein concentrate can support the sustainable recovery of CDI patients. For 31 weeks, nine dairy cows were continuously vaccinated with several anti-<i>C. difficile</i> vaccines by certain routes of administration to produce anti-<i>C. difficile</i> IgA enriched milk. The study aimed at finding decisive differences between low responder (LR) and high responder (HR) cows (> 8.0 µg ml^-1 total milk <i>C. difficile</i> specific IgA) concerning their immune response to vaccination on cellular and molecular biological levels.<h4>Results</h42018-01-01T00:00:00Z2018 Dec2026-05-05T22:23:32.617Z2019-03-27T00:12:23ZS-EPMC62888803055580510.1186/s40709-018-0092-4