{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["6(1)"],"submitter":["Truxova I"],"pubmed_abstract":["A high density of tumor-infiltrating CD8<sup>+</sup> T cells and CD20<sup>+</sup> B cells correlates with prolonged survival in patients with a wide variety of human cancers, including high-grade serous ovarian carcinoma (HGSC). However, the potential impact of mature dendritic cells (DCs) in shaping the immune contexture of HGSC, their role in the establishment of T cell-dependent antitumor immunity, and their potential prognostic value for HGSC patients remain unclear. We harnessed immunohistochemical tests and biomolecular analyses to demonstrate that a high density of tumor-infiltrating DC-LAMP<sup>+</sup> DCs is robustly associated with an immune contexture characterized by T<sub>H</sub>1 polarization and cytotoxic activity. We showed that both mature DCs and CD20<sup>+</sup> B cells play a critical role in the generation of a clinically-favorable cytotoxic immune response in HGSC microenvironment. In line with this notion, robust tumor infiltration by both DC-LAMP<sup>+</sup> DCs and CD20<sup>+</sup> B cells was associated with most favorable overall survival in two independent cohorts of chemotherapy-naïve HGSC patients. Our findings suggest that the presence of mature, DC-LAMP<sup>+</sup> DCs in the tumor microenvironment may represent a novel, powerful prognostic biomarker for HGSC patients that reflects the activation of clinically-relevant anticancer immunity."],"journal":["Journal for immunotherapy of cancer"],"pagination":["139"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6288908"],"repository":["biostudies-literature"],"pubmed_title":["Mature dendritic cells correlate with favorable immune infiltrate and improved prognosis in ovarian carcinoma patients."],"pmcid":["PMC6288908"],"pubmed_authors":["Ryska A","Hensler M","Rob L","Sautes-Fridman C","Fucikova J","Skapa P","Pecen L","Truxova I","Praznovec I","Kodet R","Spisek R","Kasikova L","Brtnicky T","Goc J","Galluzzi L","Belicova L","Halaska MJ","Fridman WH","Laco J","Salkova E"],"additional_accession":[]},"is_claimable":false,"name":"Mature dendritic cells correlate with favorable immune infiltrate and improved prognosis in ovarian carcinoma patients.","description":"A high density of tumor-infiltrating CD8<sup>+</sup> T cells and CD20<sup>+</sup> B cells correlates with prolonged survival in patients with a wide variety of human cancers, including high-grade serous ovarian carcinoma (HGSC). However, the potential impact of mature dendritic cells (DCs) in shaping the immune contexture of HGSC, their role in the establishment of T cell-dependent antitumor immunity, and their potential prognostic value for HGSC patients remain unclear. We harnessed immunohistochemical tests and biomolecular analyses to demonstrate that a high density of tumor-infiltrating DC-LAMP<sup>+</sup> DCs is robustly associated with an immune contexture characterized by T<sub>H</sub>1 polarization and cytotoxic activity. We showed that both mature DCs and CD20<sup>+</sup> B cells play a critical role in the generation of a clinically-favorable cytotoxic immune response in HGSC microenvironment. In line with this notion, robust tumor infiltration by both DC-LAMP<sup>+</sup> DCs and CD20<sup>+</sup> B cells was associated with most favorable overall survival in two independent cohorts of chemotherapy-naïve HGSC patients. Our findings suggest that the presence of mature, DC-LAMP<sup>+</sup> DCs in the tumor microenvironment may represent a novel, powerful prognostic biomarker for HGSC patients that reflects the activation of clinically-relevant anticancer immunity.","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Dec","modification":"2026-05-05T22:23:34.277Z","creation":"2019-03-27T00:11:53Z"},"accession":"S-EPMC6288908","cross_references":{"pubmed":["30526667"],"doi":["10.1186/s40425-018-0446-3"]}}