{"database":"biostudies-literature","file_versions":[],"scores":{"citationCount":0,"reanalysisCount":0,"viewCount":41,"searchCount":0},"additional":{"submitter":["Hong K"],"funding":["NIBIB NIH HHS","NIA NIH HHS","NHLBI NIH HHS","NIH HHS"],"pagination":["1219-1228"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6289847"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["81(2)"],"pubmed_abstract":["PURPOSE:To develop a wideband cardiac perfusion pulse sequence and test whether it is capable of suppressing image artifacts in patients with a cardiac implantable electronic device (CIED), while not exceeding the specific absorption rate (SAR) limit (2.0 W/kg). METHODS:A wideband perfusion pulse sequence was developed by incorporating a wideband saturation pulse to achieve a good balance between saturation of magnetization and SAR. Clinical standard and wideband perfusion MRI scans were performed back-to-back in a randomized order on 16 patients with a CIED undergoing clinical cardiac MRI. Two expert readers graded the artifact intensity and extent on a segmental basis using a 5-point Likert scale, where significant artifact was defined by a composite score. The variance in myocardial signal prior to tissue-enhancement was analyzed to quantify artifact-intensity. Whole-body SAR values computed by the MR scanner were read from the DICOM header. Either a paired t-test or Wilcoxon signed-rank test was performed to compare two groups. RESULTS:While the mean whole-body SAR for a single-slice wideband perfusion scan (0.38 ± 0.08W/kg) was significantly (p < 0.05) higher than for a single-slice standard perfusion scan (0.11 ± 0.03W/kg), it was 81% below 2.0 W/kg. The mean variance in myocardial signal prior to tissue-enhancement was significantly (p < 0.001) higher for standard (422.6 ± 306.6 a.u.) than wideband (107.0 ± 60.9 a.u.). Among 105 myocardial segments, standard produced 19 segments (18%) that were deemed to have significant artifacts, whereas wideband produced only 3 segments (3%). CONCLUSION:A wideband perfusion pulse sequence is capable of suppressing image artifacts induced by a CIED while not exceeding SAR at 2.0 W/kg."],"journal":["Magnetic resonance in medicine"],"pubmed_title":["Wideband myocardial perfusion pulse sequence for imaging patients with a cardiac implantable electronic device."],"pmcid":["PMC6289847"],"funding_grant_id":["R01HL116895","R01 HL116895","R21EB024315","R01HL138578","R01 HL138578","R21AG055954","R21 AG055954","R21 EB024315"],"pubmed_authors":["Kim D","Hong K","Carr JC","Collins JD","Lee DC","Knight BP"],"view_count":["41"],"additional_accession":[]},"is_claimable":false,"name":"Wideband myocardial perfusion pulse sequence for imaging patients with a cardiac implantable electronic device.","description":"PURPOSE:To develop a wideband cardiac perfusion pulse sequence and test whether it is capable of suppressing image artifacts in patients with a cardiac implantable electronic device (CIED), while not exceeding the specific absorption rate (SAR) limit (2.0 W/kg). METHODS:A wideband perfusion pulse sequence was developed by incorporating a wideband saturation pulse to achieve a good balance between saturation of magnetization and SAR. Clinical standard and wideband perfusion MRI scans were performed back-to-back in a randomized order on 16 patients with a CIED undergoing clinical cardiac MRI. Two expert readers graded the artifact intensity and extent on a segmental basis using a 5-point Likert scale, where significant artifact was defined by a composite score. The variance in myocardial signal prior to tissue-enhancement was analyzed to quantify artifact-intensity. Whole-body SAR values computed by the MR scanner were read from the DICOM header. Either a paired t-test or Wilcoxon signed-rank test was performed to compare two groups. RESULTS:While the mean whole-body SAR for a single-slice wideband perfusion scan (0.38 ± 0.08W/kg) was significantly (p < 0.05) higher than for a single-slice standard perfusion scan (0.11 ± 0.03W/kg), it was 81% below 2.0 W/kg. The mean variance in myocardial signal prior to tissue-enhancement was significantly (p < 0.001) higher for standard (422.6 ± 306.6 a.u.) than wideband (107.0 ± 60.9 a.u.). Among 105 myocardial segments, standard produced 19 segments (18%) that were deemed to have significant artifacts, whereas wideband produced only 3 segments (3%). CONCLUSION:A wideband perfusion pulse sequence is capable of suppressing image artifacts induced by a CIED while not exceeding SAR at 2.0 W/kg.","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Feb","modification":"2020-11-01T08:30:20Z","creation":"2020-05-22T08:44:00Z"},"accession":"S-EPMC6289847","cross_references":{"pubmed":["30229560"],"doi":["10.1002/mrm.27458"]}}