{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["9(1)"],"submitter":["Yamaguchi N"],"pubmed_abstract":["In flowering plants, the switch from floral stem cell maintenance to gynoecium (female structure) formation is a critical developmental transition for reproductive success. In Arabidopsis thaliana, AGAMOUS (AG) terminates floral stem cell activities to trigger this transition. Although CRABS CLAW (CRC) is a direct target of AG, previous research has not identified any common targets. Here, we identify an auxin synthesis gene, YUCCA4 (YUC4) as a common direct target. Ectopic YUC4 expression partially rescues the indeterminate phenotype and cell wall defects that are caused by the crc mutation. The feed-forward YUC4 activation by AG and CRC directs a precise change in chromatin state for the shift from floral stem cell maintenance to gynoecium formation. We also showed that two auxin-related direct CRC targets, YUC4 and TORNADO2, cooperatively contribute to the termination of floral stem cell maintenance. This finding provides new insight into the CRC-mediated auxin homeostasis regulation for proper gynoecium formation."],"journal":["Nature communications"],"pagination":["5290"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6289996"],"repository":["biostudies-literature"],"pubmed_title":["Chromatin-mediated feed-forward auxin biosynthesis in floral meristem determinacy."],"pmcid":["PMC6289996"],"pubmed_authors":["Yamaguchi N","Kiba T","Sugano SS","Yokoyama R","Abe M","Ito T","Tatsumi Y","Huang J","Sakakibara H","Kojima M","Nishitani K","Takebayashi Y"],"additional_accession":[]},"is_claimable":false,"name":"Chromatin-mediated feed-forward auxin biosynthesis in floral meristem determinacy.","description":"In flowering plants, the switch from floral stem cell maintenance to gynoecium (female structure) formation is a critical developmental transition for reproductive success. In Arabidopsis thaliana, AGAMOUS (AG) terminates floral stem cell activities to trigger this transition. Although CRABS CLAW (CRC) is a direct target of AG, previous research has not identified any common targets. Here, we identify an auxin synthesis gene, YUCCA4 (YUC4) as a common direct target. Ectopic YUC4 expression partially rescues the indeterminate phenotype and cell wall defects that are caused by the crc mutation. The feed-forward YUC4 activation by AG and CRC directs a precise change in chromatin state for the shift from floral stem cell maintenance to gynoecium formation. We also showed that two auxin-related direct CRC targets, YUC4 and TORNADO2, cooperatively contribute to the termination of floral stem cell maintenance. This finding provides new insight into the CRC-mediated auxin homeostasis regulation for proper gynoecium formation.","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Dec","modification":"2026-07-11T03:18:25.061Z","creation":"2026-07-11T03:08:50.358Z"},"accession":"S-EPMC6289996","cross_references":{"pubmed":["30538233"],"doi":["10.1038/s41467-018-07763-0"]}}