{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Pontin PA"],"funding":["Fundação de Amparo à Pesquisa do Estado de São Paulo"],"pagination":["316"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6290490"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(1)"],"pubmed_abstract":["Background
Posterior tibial tendon (PTT) insufficiency is considered as the main cause of adult acquired flat foot and is three times more frequent in females. High estrogen levels exert a positive effect on the overall collagen synthesis in tendons. We have previously demonstrated the association between some genetic single-nucleotide polymorphism (SNP) and tendinopathy. In the present study, we investigated the association of PvuII c454-397T>C (NCBI ID: rs2234693) and XbaI c454-351A>G (NCBI ID: rs9340799) SNPs in estrogen receptor alfa (ER-α) gene with PPT dysfunction.Methods
A total of 92 female subjects with PTT dysfunction, with histopathological examination of the tendon and magnetic resonance image (MRI) evidence of tendinopathy, were compared to 92 asymptomatic fema"],"journal":["Journal of orthopaedic surgery and research"],"pubmed_title":["ERα PvuII and XbaI polymorphisms in postmenopausal women with posterior tibial tendon dysfunction: a case control study."],"pmcid":["PMC6290490"],"funding_grant_id":["2015/19635-1"],"pubmed_authors":["Maffulli N","Godoy-Santos AL","Fonseca FCP","Carvalho KC","Cesar Netto C","Fernandes TD","Soares Junior JM","Pontin PA","Nogara PRB","Baracat EC","Santos MCL"],"additional_accession":[]},"is_claimable":false,"name":"ERα PvuII and XbaI polymorphisms in postmenopausal women with posterior tibial tendon dysfunction: a case control study.","description":"Background
Posterior tibial tendon (PTT) insufficiency is considered as the main cause of adult acquired flat foot and is three times more frequent in females. High estrogen levels exert a positive effect on the overall collagen synthesis in tendons. We have previously demonstrated the association between some genetic single-nucleotide polymorphism (SNP) and tendinopathy. In the present study, we investigated the association of PvuII c454-397T>C (NCBI ID: rs2234693) and XbaI c454-351A>G (NCBI ID: rs9340799) SNPs in estrogen receptor alfa (ER-α) gene with PPT dysfunction.Methods
A total of 92 female subjects with PTT dysfunction, with histopathological examination of the tendon and magnetic resonance image (MRI) evidence of tendinopathy, were compared to 92 asymptomatic fema","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Dec","modification":"2025-04-19T15:31:37.108Z","creation":"2019-03-27T00:12:24Z"},"accession":"S-EPMC6290490","cross_references":{"pubmed":["30537990"],"doi":["10.1186/s13018-018-1020-x"]}}