biostudies-literaturePontin PAFundação de Amparo à Pesquisa do Estado de São Paulo316https://www.ebi.ac.uk/biostudies/studies/S-EPMC6290490biostudies-literatureUnknown13(1)<h4>Background</h4>Posterior tibial tendon (PTT) insufficiency is considered as the main cause of adult acquired flat foot and is three times more frequent in females. High estrogen levels exert a positive effect on the overall collagen synthesis in tendons. We have previously demonstrated the association between some genetic single-nucleotide polymorphism (SNP) and tendinopathy. In the present study, we investigated the association of PvuII c454-397T>C (NCBI ID: rs2234693) and XbaI c454-351A>G (NCBI ID: rs9340799) SNPs in estrogen receptor alfa (ER-α) gene with PPT dysfunction.<h4>Methods</h4>A total of 92 female subjects with PTT dysfunction, with histopathological examination of the tendon and magnetic resonance image (MRI) evidence of tendinopathy, were compared to 92 asymptomatic femaJournal of orthopaedic surgery and researchERα PvuII and XbaI polymorphisms in postmenopausal women with posterior tibial tendon dysfunction: a case control study.PMC62904902015/19635-1Maffulli NGodoy-Santos ALFonseca FCPCarvalho KCCesar Netto CFernandes TDSoares Junior JMPontin PANogara PRBBaracat ECSantos MCLfalseERα PvuII and XbaI polymorphisms in postmenopausal women with posterior tibial tendon dysfunction: a case control study.<h4>Background</h4>Posterior tibial tendon (PTT) insufficiency is considered as the main cause of adult acquired flat foot and is three times more frequent in females. High estrogen levels exert a positive effect on the overall collagen synthesis in tendons. We have previously demonstrated the association between some genetic single-nucleotide polymorphism (SNP) and tendinopathy. In the present study, we investigated the association of PvuII c454-397T>C (NCBI ID: rs2234693) and XbaI c454-351A>G (NCBI ID: rs9340799) SNPs in estrogen receptor alfa (ER-α) gene with PPT dysfunction.<h4>Methods</h4>A total of 92 female subjects with PTT dysfunction, with histopathological examination of the tendon and magnetic resonance image (MRI) evidence of tendinopathy, were compared to 92 asymptomatic fema2018-01-01T00:00:00Z2018 Dec2025-04-19T15:31:37.108Z2019-03-27T00:12:24ZS-EPMC62904903053799010.1186/s13018-018-1020-x