biostudies-literatureDe Leon ERU.S. Department of Health & Human Services | National Institutes of HealthBLRD VANIDDK NIH HHSNIA NIH HHSAmerican Diabetes AssociationU.S. Department of Health & Human Services | National Institutes of Health (NIH)American Diabetes Association (ADA)17814https://www.ebi.ac.uk/biostudies/studies/S-EPMC6292902biostudies-literatureUnknown8(1)Type 2 diabetes is an age-and-obesity associated disease driven by impairments in glucose homeostasis that ultimately result in defective insulin secretion from pancreatic β-cells. To deconvolve the effects of age and obesity in an experimental model of prediabetes, we fed young and aged mice either chow or a short-term high-fat/high-sucrose Western diet (WD) and examined how weight, glucose tolerance, and β-cell function were affected. Although WD induced a similar degree of weight gain in young and aged mice, a high degree of heterogeneity was found exclusively in aged mice. Weight gain in WD-fed aged mice was well-correlated with glucose intolerance, fasting insulin, and in vivo glucose-stimulated insulin secretion, relationships that were not observed in young animals. Although β-cell Scientific reportsAge-Dependent Protection of Insulin Secretion in Diet Induced Obese Mice.PMC62929021-16-IBS-212R21 AG051974F31 DK109698AG051974R21 AG050135DK113103R00 AG041765R01 DK113103R01 AG056771AG041765DK102598R01 DK102598AG056771DK101683I01 BX004031T32GM008349T32 AG000213AG050135K01 DK101683Fenske RJSchmidt BAKimple MEBrinkman JASherman DSMerrins MJCummings NEPeter DCLamming DWGregg TDe Leon ERfalseAge-Dependent Protection of Insulin Secretion in Diet Induced Obese Mice.Type 2 diabetes is an age-and-obesity associated disease driven by impairments in glucose homeostasis that ultimately result in defective insulin secretion from pancreatic β-cells. To deconvolve the effects of age and obesity in an experimental model of prediabetes, we fed young and aged mice either chow or a short-term high-fat/high-sucrose Western diet (WD) and examined how weight, glucose tolerance, and β-cell function were affected. Although WD induced a similar degree of weight gain in young and aged mice, a high degree of heterogeneity was found exclusively in aged mice. Weight gain in WD-fed aged mice was well-correlated with glucose intolerance, fasting insulin, and in vivo glucose-stimulated insulin secretion, relationships that were not observed in young animals. Although β-cell 2018-01-01T00:00:00Z2018 Dec2026-07-16T16:44:15.38Z2019-03-27T00:13:13ZS-EPMC62929023054603110.1038/s41598-018-36289-0