{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wu Q"],"funding":["National Natural Science Foundation of China","National Cancer Institute","NCI NIH HHS"],"pagination":["582-594"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6294659"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["144(3)"],"pubmed_abstract":["Krüppel-like factor 5 (KLF5) both suppresses and promotes tumor growth depending on cellular context. The mechanisms underlying tumor promotion could be targetable for therapy. Although a number of transcriptional targets of KLF5 have been identified and implicated in KLF5-mediated tumor growth, how KLF5 regulates these genes remains to be addressed. Here we performed coimmunoprecipitation (co-IP) and liquid chromatography-tandem mass spectrometry (LC-MS/MS) in the TSU-Pr1 bladder cancer cell line, in which KLF5 is shown to promote tumor growth, to identify KLF5-interacting nuclear proteins that are necessary for KLF5's tumor promoting function. LC-MS/MS revealed 122 potential KLF5 binding proteins in the nuclear proteins precipitated by the KLF5 antibody, and the top nine candidates inclu"],"journal":["International journal of cancer"],"pubmed_title":["CINP is a novel cofactor of KLF5 required for its role in the promotion of cell proliferation, survival and tumor growth."],"pmcid":["PMC6294659"],"funding_grant_id":["R01 CA171189","R01CA171189","81130044"],"pubmed_authors":["Gao A","Qi L","Li J","An N","Liu M","Wu Q","Fu X","Dong JT","A J","Li M","Li Y","Fu C","Li Z","King JL","Fu L","Zhang B","Ci X","Ma G"],"additional_accession":[]},"is_claimable":false,"name":"CINP is a novel cofactor of KLF5 required for its role in the promotion of cell proliferation, survival and tumor growth.","description":"Krüppel-like factor 5 (KLF5) both suppresses and promotes tumor growth depending on cellular context. The mechanisms underlying tumor promotion could be targetable for therapy. Although a number of transcriptional targets of KLF5 have been identified and implicated in KLF5-mediated tumor growth, how KLF5 regulates these genes remains to be addressed. Here we performed coimmunoprecipitation (co-IP) and liquid chromatography-tandem mass spectrometry (LC-MS/MS) in the TSU-Pr1 bladder cancer cell line, in which KLF5 is shown to promote tumor growth, to identify KLF5-interacting nuclear proteins that are necessary for KLF5's tumor promoting function. LC-MS/MS revealed 122 potential KLF5 binding proteins in the nuclear proteins precipitated by the KLF5 antibody, and the top nine candidates inclu","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Feb","modification":"2026-05-06T01:23:57.31Z","creation":"2020-10-29T11:01:41Z"},"accession":"S-EPMC6294659","cross_references":{"pubmed":["30289973"],"doi":["10.1002/ijc.31908"]}}