{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Phe K"],"funding":["NIAID NIH HHS"],"pagination":["3585-3587"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6296320"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["71(12)"],"pubmed_abstract":["Objectives
With increasing rates of infections caused by MDR Gram-negative organisms, clinicians resort to older agents such as colistimethate sodium (CMS) despite a significant risk of nephrotoxicity. Several risk factors for CMS-associated nephrotoxicity have been reported, but they have yet to be validated. We compared the performance of published mathematical models in predicting the risk of CMS-associated nephrotoxicity.Methods
In a multicentre, retrospective, cohort study, adult patients (≥18 years of age) were evaluated from five large academic medical centres in the USA. Patients with normal renal function (baseline serum creatinine ≤1.5 mg/dL) who received intravenous CMS for ≥72 h were followed for up to 30 days. The development of nephrotoxicity was as defined by"],"journal":["The Journal of antimicrobial chemotherapy"],"pubmed_title":["Predicting the risk of nephrotoxicity in patients receiving colistimethate sodium: a multicentre, retrospective, cohort study."],"pmcid":["PMC6296320"],"funding_grant_id":["K08 AI114883"],"pubmed_authors":["Phe K","Shields RK","Tam VH","Luce AM","Aitken SL","Lam WM","Tverdek FP","Musgrove RJ","Guervil DJ"],"additional_accession":[]},"is_claimable":false,"name":"Predicting the risk of nephrotoxicity in patients receiving colistimethate sodium: a multicentre, retrospective, cohort study.","description":"Objectives
With increasing rates of infections caused by MDR Gram-negative organisms, clinicians resort to older agents such as colistimethate sodium (CMS) despite a significant risk of nephrotoxicity. Several risk factors for CMS-associated nephrotoxicity have been reported, but they have yet to be validated. We compared the performance of published mathematical models in predicting the risk of CMS-associated nephrotoxicity.Methods
In a multicentre, retrospective, cohort study, adult patients (≥18 years of age) were evaluated from five large academic medical centres in the USA. Patients with normal renal function (baseline serum creatinine ≤1.5 mg/dL) who received intravenous CMS for ≥72 h were followed for up to 30 days. The development of nephrotoxicity was as defined by","dates":{"release":"2016-01-01T00:00:00Z","publication":"2016 Dec","modification":"2025-04-04T22:30:09.777Z","creation":"2019-03-27T00:13:15Z"},"accession":"S-EPMC6296320","cross_references":{"pubmed":["27543655"],"doi":["10.1093/jac/dkw329"]}}