biostudies-literaturePhe KNIAID NIH HHS3585-3587https://www.ebi.ac.uk/biostudies/studies/S-EPMC6296320biostudies-literatureUnknown71(12)<h4>Objectives</h4>With increasing rates of infections caused by MDR Gram-negative organisms, clinicians resort to older agents such as colistimethate sodium (CMS) despite a significant risk of nephrotoxicity. Several risk factors for CMS-associated nephrotoxicity have been reported, but they have yet to be validated. We compared the performance of published mathematical models in predicting the risk of CMS-associated nephrotoxicity.<h4>Methods</h4>In a multicentre, retrospective, cohort study, adult patients (≥18 years of age) were evaluated from five large academic medical centres in the USA. Patients with normal renal function (baseline serum creatinine ≤1.5 mg/dL) who received intravenous CMS for ≥72 h were followed for up to 30 days. The development of nephrotoxicity was as defined byThe Journal of antimicrobial chemotherapyPredicting the risk of nephrotoxicity in patients receiving colistimethate sodium: a multicentre, retrospective, cohort study.PMC6296320K08 AI114883Phe KShields RKTam VHLuce AMAitken SLLam WMTverdek FPMusgrove RJGuervil DJfalsePredicting the risk of nephrotoxicity in patients receiving colistimethate sodium: a multicentre, retrospective, cohort study.<h4>Objectives</h4>With increasing rates of infections caused by MDR Gram-negative organisms, clinicians resort to older agents such as colistimethate sodium (CMS) despite a significant risk of nephrotoxicity. Several risk factors for CMS-associated nephrotoxicity have been reported, but they have yet to be validated. We compared the performance of published mathematical models in predicting the risk of CMS-associated nephrotoxicity.<h4>Methods</h4>In a multicentre, retrospective, cohort study, adult patients (≥18 years of age) were evaluated from five large academic medical centres in the USA. Patients with normal renal function (baseline serum creatinine ≤1.5 mg/dL) who received intravenous CMS for ≥72 h were followed for up to 30 days. The development of nephrotoxicity was as defined by2016-01-01T00:00:00Z2016 Dec2025-04-04T22:30:09.777Z2019-03-27T00:13:15ZS-EPMC62963202754365510.1093/jac/dkw329