{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Espino SS"],"funding":["NEI NIH HHS","NIAID NIH HHS","National Institute of Health","National Institutes of Health","NIGMS NIH HHS"],"pagination":["28-34"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6299835"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["154"],"pubmed_abstract":["Members of Mas related G-protein coupled receptors (Mrgpr) are known to mediate itch. To date, several compounds have been shown to activate these receptors, including chloroquine, a common antimalarial drug, and peptides of the RF-amide family. However, specific ligands for these receptors are still lacking and there is a need for novel compounds that can be used to modulate the receptors in order to understand the cellular and molecular mechanism in which they mediate itch. Some cone snail venoms were previously shown to induce itch in mice. Here, we show that the venom of Conus textile induces itch through activation of itch-sensing sensory neurons, marked by their sensitivity to chloroquine. Two RF-amide peptides, CNF-Tx1 and CNF-Tx2, were identified in a C. textile venom gland transcr"],"journal":["Toxicon : official journal of the International Society on Toxinology"],"pubmed_title":["Conopeptides promote itch through human itch receptor hMgprX1."],"pmcid":["PMC6299835"],"funding_grant_id":["P01 GM048677","1R01AI125743","R01 EY024704","R01 AI125743","PO1 GM48677","R01EY024704"],"pubmed_authors":["Safavi-Hemami H","Yang W","Espino SS","Robinson SD","Liu Q","Olivera BM","Gajewiak J"],"additional_accession":[]},"is_claimable":false,"name":"Conopeptides promote itch through human itch receptor hMgprX1.","description":"Members of Mas related G-protein coupled receptors (Mrgpr) are known to mediate itch. To date, several compounds have been shown to activate these receptors, including chloroquine, a common antimalarial drug, and peptides of the RF-amide family. However, specific ligands for these receptors are still lacking and there is a need for novel compounds that can be used to modulate the receptors in order to understand the cellular and molecular mechanism in which they mediate itch. Some cone snail venoms were previously shown to induce itch in mice. Here, we show that the venom of Conus textile induces itch through activation of itch-sensing sensory neurons, marked by their sensitivity to chloroquine. Two RF-amide peptides, CNF-Tx1 and CNF-Tx2, were identified in a C. textile venom gland transcr","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Nov","modification":"2026-04-14T13:38:15.618Z","creation":"2019-11-07T08:02:53Z"},"accession":"S-EPMC6299835","cross_references":{"pubmed":["30243794"],"doi":["10.1016/j.toxicon.2018.09.002"]}}