{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Dagleish MP"],"funding":["Medical Research Council","Biotechnology and Biological Sciences Research Council","Scottish Government"],"pagination":["23-32"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6302148"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["165"],"pubmed_abstract":["Louping-ill (LI), caused by louping-ill virus (LIV), results in a frequently fatal encephalitis primarily affecting sheep and red grouse (Lagopus lagopus scotica), but it does occur in other species. An adult male Border collie dog was definitively diagnosed with fatal LI and the lesion profile, LIV antigen distribution and full genome sequence of the LIV responsible were investigated to determine if this differed significantly from sheep-derived LIV. No gross lesions were present. The histological lesions were confined to the central nervous system and comprised of lymphocytic perivascular cuffs, glial foci, neuronal necrosis and neuronophagia. Immunolocalization of viral antigen showed small amounts present in neurons only. These histological and immunohistochemical findings were similar"],"journal":["Journal of comparative pathology"],"pubmed_title":["A Fatal Case of Louping-ill in a Dog: Immunolocalization and Full Genome Sequencing of the Virus."],"pmcid":["PMC6302148"],"funding_grant_id":["BB/J013854/1","1518059","MC_UU_12014/8","MC_UU_12014/12"],"pubmed_authors":["Clark JJ","Robson C","Rocchi MS","Dagleish MP","Orton RJ","Tucker M"],"additional_accession":[]},"is_claimable":false,"name":"A Fatal Case of Louping-ill in a Dog: Immunolocalization and Full Genome Sequencing of the Virus.","description":"Louping-ill (LI), caused by louping-ill virus (LIV), results in a frequently fatal encephalitis primarily affecting sheep and red grouse (Lagopus lagopus scotica), but it does occur in other species. An adult male Border collie dog was definitively diagnosed with fatal LI and the lesion profile, LIV antigen distribution and full genome sequence of the LIV responsible were investigated to determine if this differed significantly from sheep-derived LIV. No gross lesions were present. The histological lesions were confined to the central nervous system and comprised of lymphocytic perivascular cuffs, glial foci, neuronal necrosis and neuronophagia. Immunolocalization of viral antigen showed small amounts present in neurons only. These histological and immunohistochemical findings were similar","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Nov","modification":"2026-04-08T05:00:19.931Z","creation":"2019-03-27T00:14:35Z"},"accession":"S-EPMC6302148","cross_references":{"pubmed":["30502792"],"doi":["10.1016/j.jcpa.2018.09.004"]}}