biostudies-literatureGarg PBritish Heart FoundationDutch ZonMwNational Institute for Health Research (NIHR)ZonMw108-117https://www.ebi.ac.uk/biostudies/studies/S-EPMC6302263biostudies-literatureUnknown20(1)<h4>Aims</h4>The main aim of this study was to characterize changes in the left ventricular (LV) blood flow kinetic energy (KE) using four-dimensional (4D) flow cardiovascular magnetic resonance imaging (CMR) in patients with myocardial infarction (MI) with/without LV thrombus (LVT).<h4>Methods and results</h4>This is a prospective cohort study of 108 subjects [controls = 40, MI patients without LVT (LVT- = 36), and MI patients with LVT (LVT+ = 32)]. All underwent CMR including whole-heart 4D flow. LV blood flow KE wall calculated using the formula: KE=12 ρblood . Vvoxel . v2, where ρ = density, V = volume, v = velocity, and was indexed to LV end-diastolic volume. Patient with MI had significantly lower LV KE components than controls (P < 0.05). LVT+ and LVT- patients had comparable infarcEuropean heart journal. Cardiovascular ImagingLeft ventricular thrombus formation in myocardial infarction is associated with altered left ventricular blood flow energetics.PMC6302263CL-2017-02-002104003001FS/10/62/28409Dobson LEBissell MVijayan Svan der Geest RJGreenwood JPBrown LAEGarg PAl Musa TFent GJCrandon SHassell MECJWestenberg JJMFoley JRJSwoboda PPOnciul SNijveldt RElbaz MSMChew PGDall'Armellina EPlein SfalseLeft ventricular thrombus formation in myocardial infarction is associated with altered left ventricular blood flow energetics.<h4>Aims</h4>The main aim of this study was to characterize changes in the left ventricular (LV) blood flow kinetic energy (KE) using four-dimensional (4D) flow cardiovascular magnetic resonance imaging (CMR) in patients with myocardial infarction (MI) with/without LV thrombus (LVT).<h4>Methods and results</h4>This is a prospective cohort study of 108 subjects [controls = 40, MI patients without LVT (LVT- = 36), and MI patients with LVT (LVT+ = 32)]. All underwent CMR including whole-heart 4D flow. LV blood flow KE wall calculated using the formula: KE=12 ρblood . Vvoxel . v2, where ρ = density, V = volume, v = velocity, and was indexed to LV end-diastolic volume. Patient with MI had significantly lower LV KE components than controls (P < 0.05). LVT+ and LVT- patients had comparable infarc2019-01-01T00:00:00Z2019 Jan2025-04-04T13:07:39.997Z2019-03-27T00:14:34ZS-EPMC63022633013727410.1093/ehjci/jey121