{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Abu-Izneid T"],"funding":["Umm Al-Qura University"],"pagination":["8648956"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6304533"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["2018"],"pubmed_abstract":["The aim of the current study was to synthesize new bioactive compounds and evaluate their therapeutic relevance. The chemical structure of compound <b>7</b> (methyl 3-O-phospo-<i>α</i>-D-glucopyranuronic acid was elucidated by physical and advance spectral technique. Also, this compound was assessed for various <i>in vitro</i> biological screening. The results showed that compound <b>7</b> has promising antifungal activity against selected fungal strains. Computational study was also carried out to find antimalarial efficacy of the synthesized compounds. Compounds (<b>2-7</b>) were tested for cytotoxicity by MTT assay, and no considerable cytotoxicity was observed. Molecular docking study was performed to predict the binding modes of new compound (<b>7</b>). The docking results revealed th"],"journal":["BioMed research international"],"pubmed_title":["Anti-Dengue, Cytotoxicity, Antifungal, and <i>In Silico</i> Study of the Newly Synthesized 3-<i>O</i>-Phospo-α-<i>D</i>-Glucopyranuronic Acid Compound."],"pmcid":["PMC6304533"],"funding_grant_id":["15- MED-3-1-0026"],"pubmed_authors":["Abu-Izneid T","Bawazeer S","Patel S","Rauf A","Wadood A"],"additional_accession":[]},"is_claimable":false,"name":"Anti-Dengue, Cytotoxicity, Antifungal, and <i>In Silico</i> Study of the Newly Synthesized 3-<i>O</i>-Phospo-α-<i>D</i>-Glucopyranuronic Acid Compound.","description":"The aim of the current study was to synthesize new bioactive compounds and evaluate their therapeutic relevance. The chemical structure of compound <b>7</b> (methyl 3-O-phospo-<i>α</i>-D-glucopyranuronic acid was elucidated by physical and advance spectral technique. Also, this compound was assessed for various <i>in vitro</i> biological screening. The results showed that compound <b>7</b> has promising antifungal activity against selected fungal strains. Computational study was also carried out to find antimalarial efficacy of the synthesized compounds. Compounds (<b>2-7</b>) were tested for cytotoxicity by MTT assay, and no considerable cytotoxicity was observed. Molecular docking study was performed to predict the binding modes of new compound (<b>7</b>). The docking results revealed th","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018","modification":"2025-04-22T15:25:56.225Z","creation":"2019-03-26T22:36:43Z"},"accession":"S-EPMC6304533","cross_references":{"pubmed":["30627577"],"doi":["10.1155/2018/8648956"]}}