biostudies-literatureSwain SCrohn&apos;s and Colitis Foundation of AmericaNIDDK NIH HHSRuth K. Broad Biomedical Research FoundationCrohn's & Colitis FoundationNational Institutes of HealthM.J. Murdock Charitable TrustNIGMS NIH HHS2989https://www.ebi.ac.uk/biostudies/studies/S-EPMC6308147biostudies-literatureUnknown9Dendritic cell (DC) expression of CD103, the α subunit of αEβ7 integrin, is thought to enable DC interactions with E-cadherin-expressing gastrointestinal epithelia for improved mucosal immunosurveillance. In the stomach, efficient DC surveillance of the epithelial barrier is crucial for the induction of immune responses to <i>H. pylori</i>, the causative agent of peptic ulcers and gastric cancer. However, gastric DCs express only low levels of surface CD103, as we previously showed. We here tested the hypothesis that intracellular pools of CD103 in human gastric DCs can be redistributed to the cell surface for engagement of epithelial cell-expressed E-cadherin to promote DC-epithelial cell adhesion. In support of our hypothesis, immunofluorescence analysis of tissue sections showed that CDFrontiers in immunologyCD103 (αE Integrin) Undergoes Endosomal Trafficking in Human Dendritic Cells, but Does Not Mediate Epithelial Adhesion.PMC6308147GM110732R03 DK107960K01 DK097144294174P30 GM110732Sidar BDankoff JVanAusdol RSmythies LESmith PDSwain SSebrell TARoe MMBimczok DfalseCD103 (αE Integrin) Undergoes Endosomal Trafficking in Human Dendritic Cells, but Does Not Mediate Epithelial Adhesion.Dendritic cell (DC) expression of CD103, the α subunit of αEβ7 integrin, is thought to enable DC interactions with E-cadherin-expressing gastrointestinal epithelia for improved mucosal immunosurveillance. In the stomach, efficient DC surveillance of the epithelial barrier is crucial for the induction of immune responses to <i>H. pylori</i>, the causative agent of peptic ulcers and gastric cancer. However, gastric DCs express only low levels of surface CD103, as we previously showed. We here tested the hypothesis that intracellular pools of CD103 in human gastric DCs can be redistributed to the cell surface for engagement of epithelial cell-expressed E-cadherin to promote DC-epithelial cell adhesion. In support of our hypothesis, immunofluorescence analysis of tissue sections showed that CD2018-01-01T00:00:00Z20182026-06-19T03:14:39.26Z2026-06-19T03:07:40.571ZS-EPMC63081473062253110.3389/fimmu.2018.02989