{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kim J"],"funding":["NICHD NIH HHS","NIDDK NIH HHS","Howard Hughes Medical Institute","National Heart, Lung, and Blood Institute","NHLBI NIH HHS","NCI NIH HHS","National Institutes of Health"],"pagination":["39"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6309084"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["8(1)"],"pubmed_abstract":["<h4>Background</h4>β<sub>2</sub>-adrenergic receptors (β<sub>2</sub>ARs) are the target of catecholamines and play fundamental roles in cardiovascular, pulmonary, and skeletal muscle physiology. An important action of β<sub>2</sub>AR stimulation on skeletal muscle is anabolic growth, which has led to the use of agonists such as clenbuterol by athletes to enhance muscle performance. While previous work has demonstrated that β<sub>2</sub>ARs can engage distinct signaling and functional cascades mediated by either G proteins or the multifunctional adaptor protein, β-arrestin, the precise role of β-arrestin in skeletal muscle physiology is not known. Here, we tested the hypothesis that agonist activation of the β<sub>2</sub>AR by clenbuterol would engage β-arrestin as a key transducer of anabo"],"journal":["Skeletal muscle"],"pubmed_title":["β-arrestin 1 regulates β2-adrenergic receptor-mediated skeletal muscle hypertrophy and contractility."],"pmcid":["PMC6309084"],"funding_grant_id":["P01 HL075443","HD070872","R01-CA172570","K08 HL133488","R01 CA172570","K12 CA100639","HL056687","HL133488","R01 HL056687","HL16037","R01 DK109911","R01 HL016037","DK109911","5K12-CA100639-08","K08 HD070872","None","HL075443"],"pubmed_authors":["Li T","Chen M","Chen W","Grotegut CA","Rosenberg PB","Kim J","Lefkowitz RJ","Wisler JW","Mao L","Rockman HA"],"additional_accession":[]},"is_claimable":false,"name":"β-arrestin 1 regulates β2-adrenergic receptor-mediated skeletal muscle hypertrophy and contractility.","description":"<h4>Background</h4>β<sub>2</sub>-adrenergic receptors (β<sub>2</sub>ARs) are the target of catecholamines and play fundamental roles in cardiovascular, pulmonary, and skeletal muscle physiology. An important action of β<sub>2</sub>AR stimulation on skeletal muscle is anabolic growth, which has led to the use of agonists such as clenbuterol by athletes to enhance muscle performance. While previous work has demonstrated that β<sub>2</sub>ARs can engage distinct signaling and functional cascades mediated by either G proteins or the multifunctional adaptor protein, β-arrestin, the precise role of β-arrestin in skeletal muscle physiology is not known. Here, we tested the hypothesis that agonist activation of the β<sub>2</sub>AR by clenbuterol would engage β-arrestin as a key transducer of anabo","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Dec","modification":"2025-04-21T21:33:47.838Z","creation":"2019-03-26T22:33:50Z"},"accession":"S-EPMC6309084","cross_references":{"pubmed":["30591079"],"doi":["10.1186/s13395-018-0184-8"]}}