{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Vongpatanasin W"],"funding":["NCATS NIH HHS","NIA NIH HHS","NHLBI NIH HHS"],"pagination":["1312-1319"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6309342"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["72(6)"],"pubmed_abstract":["Most guidelines have recommended lower home blood pressure (BP) threshold when clinic BP threshold of 140/90 mm?Hg is used for diagnosis of hypertension. However, home BP thresholds to define hypertension have never been determined in the general population in the United States. We identified home BP thresholds for stage 1 (BP ?130/80 mm?Hg) hypertension using a regression-based approach in the DHS (Dallas Heart Study; n=5768) and the NCMH study (North Carolina Masked Hypertension; n=420). Home BP thresholds were also assessed using outcome-derived approach based on the composite of all-cause mortality or cardiovascular events in the DHS cohort. For this approach, BP thresholds were identified only for systolic BP because diastolic BP was not associated with the outcome. Among untreated participants, the regression-derived thresholds for home BP corresponding to clinic BP for stage 1 hypertension were 129/80 mm?Hg in blacks, 130/80 mm?Hg in whites, and 126/78 mm?Hg in Hispanics, respectively. The results are similar in the North Carolina cohort. The 11-year composite cardiovascular and mortality events corresponding to clinic systolic BP >130 mm?Hg were higher in blacks than in whites and Hispanics (13.3% versus 5.98% versus 5.52%, respectively). Using a race/ethnicity-specific composite outcome in the untreated DHS participants, the outcome-derived home systolic BP thresholds corresponding to stage 1 hypertension were 130 mm?Hg in blacks, 129 mm?Hg in whites, and 131 mm?Hg in Hispanics, respectively. Our data based on both regression-derived and outcome approach support home BP threshold of 130/80 mm?Hg for diagnosis of hypertension in blacks, whites, and Hispanics."],"journal":["Hypertension (Dallas, Tex. : 1979)"],"pubmed_title":["Diagnostic Thresholds for Blood Pressure Measured at Home in the Context of the 2017 Hypertension Guideline."],"pmcid":["PMC6309342"],"funding_grant_id":["R01 HL133179","R01 HL098604","R01 AG057571","UL1 TR001105"],"pubmed_authors":["de Lemos JA","Ayers C","Lin FC","Khera A","Viera AJ","Vongpatanasin W","Victor RG","Yano Y","Das SR","Berry JD","Lodhi H"],"additional_accession":[]},"is_claimable":false,"name":"Diagnostic Thresholds for Blood Pressure Measured at Home in the Context of the 2017 Hypertension Guideline.","description":"Most guidelines have recommended lower home blood pressure (BP) threshold when clinic BP threshold of 140/90 mm?Hg is used for diagnosis of hypertension. However, home BP thresholds to define hypertension have never been determined in the general population in the United States. We identified home BP thresholds for stage 1 (BP ?130/80 mm?Hg) hypertension using a regression-based approach in the DHS (Dallas Heart Study; n=5768) and the NCMH study (North Carolina Masked Hypertension; n=420). Home BP thresholds were also assessed using outcome-derived approach based on the composite of all-cause mortality or cardiovascular events in the DHS cohort. For this approach, BP thresholds were identified only for systolic BP because diastolic BP was not associated with the outcome. Among untreated participants, the regression-derived thresholds for home BP corresponding to clinic BP for stage 1 hypertension were 129/80 mm?Hg in blacks, 130/80 mm?Hg in whites, and 126/78 mm?Hg in Hispanics, respectively. The results are similar in the North Carolina cohort. The 11-year composite cardiovascular and mortality events corresponding to clinic systolic BP >130 mm?Hg were higher in blacks than in whites and Hispanics (13.3% versus 5.98% versus 5.52%, respectively). Using a race/ethnicity-specific composite outcome in the untreated DHS participants, the outcome-derived home systolic BP thresholds corresponding to stage 1 hypertension were 130 mm?Hg in blacks, 129 mm?Hg in whites, and 131 mm?Hg in Hispanics, respectively. Our data based on both regression-derived and outcome approach support home BP threshold of 130/80 mm?Hg for diagnosis of hypertension in blacks, whites, and Hispanics.","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Dec","modification":"2020-10-31T09:48:55Z","creation":"2020-05-21T20:20:12Z"},"accession":"S-EPMC6309342","cross_references":{"pubmed":["30571225"],"doi":["10.1161/HYPERTENSIONAHA.118.11657","10.1161/hypertensionaha.118.11657"]}}