{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Li L"],"funding":["Ministry of Science and Technology of the People's Republic of China","National Natural Science Foundation of China"],"pagination":["bio035444"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6310889"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["7(12)"],"pubmed_abstract":["Pharyngeal pouches, a series of outpocketings derived from the foregut endoderm, are essential for craniofacial skeleton formation. However, the molecular mechanisms underlying endodermal pouch-regulated head cartilage development are not fully understood. In this study, we find that zebrafish dmrt2b, a gene encoding Doublesex- and Mab-3-related transcription factor, is specifically expressed in endodermal pouches and required for normal pharyngeal cartilage development. Loss of dmrt2b doesn't affect cranial neural crest (CNC) specification and migration, but leads to prechondrogenic condensation defects by reducing cxcl12b expression after CNC cell movement into the pharyngeal arches. Moreover, dmrt2b inactivation results in reduced proliferation and impaired differentiation of CNC cells."],"journal":["Biology open"],"pubmed_title":["Endodermal pouch-expressed dmrt2b is important for pharyngeal cartilage formation."],"pmcid":["PMC6310889"],"funding_grant_id":["2016YFA0100503","31571501"],"pubmed_authors":["Wang P","Wang Q","Mao A","Cao Y","Li L","Ning G"],"additional_accession":[]},"is_claimable":false,"name":"Endodermal pouch-expressed dmrt2b is important for pharyngeal cartilage formation.","description":"Pharyngeal pouches, a series of outpocketings derived from the foregut endoderm, are essential for craniofacial skeleton formation. However, the molecular mechanisms underlying endodermal pouch-regulated head cartilage development are not fully understood. In this study, we find that zebrafish dmrt2b, a gene encoding Doublesex- and Mab-3-related transcription factor, is specifically expressed in endodermal pouches and required for normal pharyngeal cartilage development. Loss of dmrt2b doesn't affect cranial neural crest (CNC) specification and migration, but leads to prechondrogenic condensation defects by reducing cxcl12b expression after CNC cell movement into the pharyngeal arches. Moreover, dmrt2b inactivation results in reduced proliferation and impaired differentiation of CNC cells.","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Dec","modification":"2025-04-21T21:40:40.39Z","creation":"2019-03-26T22:27:50Z"},"accession":"S-EPMC6310889","cross_references":{"pubmed":["30341107"],"doi":["10.1242/bio.035444"]}}