biostudies-literatureUnknown364Toews I<h4>Objective</h4>To assess the association between intake of non-sugar sweeteners (NSS) and important health outcomes in generally healthy or overweight/obese adults and children.<h4>Design</h4>Systematic review following standard Cochrane review methodology.<h4>Data sources</h4>Medline (Ovid), Embase, Cochrane CENTRAL, WHO International Clinical Trials Registry Platform, Clinicaltrials.gov, and reference lists of relevant publications.<h4>Eligibility criteria for selecting studies</h4>Studies including generally healthy adults or children with or without overweight or obesity were eligible. Included study designs allowed for a direct comparison of no intake or lower intake of NSS with higher NSS intake. NSSs had to be clearly named, the dose had to be within the acceptable daily intake, BMJ (Clinical research ed.)k4718https://www.ebi.ac.uk/biostudies/studies/S-EPMC6313893biostudies-literatureAssociation between intake of non-sugar sweeteners and health outcomes: systematic review and meta-analyses of randomised and non-randomised controlled trials and observational studies.PMC6313893Meerpohl JJKullenberg de Gaudry DToews ISommer HLohner SfalseAssociation between intake of non-sugar sweeteners and health outcomes: systematic review and meta-analyses of randomised and non-randomised controlled trials and observational studies.<h4>Objective</h4>To assess the association between intake of non-sugar sweeteners (NSS) and important health outcomes in generally healthy or overweight/obese adults and children.<h4>Design</h4>Systematic review following standard Cochrane review methodology.<h4>Data sources</h4>Medline (Ovid), Embase, Cochrane CENTRAL, WHO International Clinical Trials Registry Platform, Clinicaltrials.gov, and reference lists of relevant publications.<h4>Eligibility criteria for selecting studies</h4>Studies including generally healthy adults or children with or without overweight or obesity were eligible. Included study designs allowed for a direct comparison of no intake or lower intake of NSS with higher NSS intake. NSSs had to be clearly named, the dose had to be within the acceptable daily intake, 2019-01-01T00:00:00Z2019 Jan2025-04-05T00:31:57.818Z2019-03-26T22:37:32ZS-EPMC63138933060257710.1136/bmj.k4718