{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ye S"],"funding":["Perelman School of Medicine, University of Pennsylvania (Perelman School of Medicine)","NCI NIH HHS","Penn Sarcoma Program","NIAMS NIH HHS","HHS | NIH | National Cancer Institute (NCI)","Steps to Cure Sarcoma"],"pagination":["2705-2720"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6314302"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["78(10)"],"pubmed_abstract":["To date, no consistent oncogenic driver mutations have been identified in most adult soft tissue sarcomas; these tumors are thus generally insensitive to existing targeted therapies. Here we investigated alternate mechanisms underlying sarcomagenesis to identify potential therapeutic interventions. Undifferentiated pleomorphic sarcoma (UPS) is an aggressive tumor frequently found in skeletal muscle where deregulation of the Hippo pathway and aberrant stabilization of its transcriptional effector yes-associated protein 1 (YAP1) increases proliferation and tumorigenesis. However, the downstream mechanisms driving this deregulation are incompletely understood. Using autochthonous mouse models and whole genome analyses, we found that YAP1 was constitutively active in some sarcomas due to epige"],"journal":["Cancer research"],"pubmed_title":["YAP1-Mediated Suppression of USP31 Enhances NFκB Activity to Promote Sarcomagenesis."],"pmcid":["PMC6314302"],"funding_grant_id":["internal","CA100707","T32 AR007465","P50 CA100707"],"pubmed_authors":["Weber K","Lawlor MA","Ciotti GE","Xu M","Haldar M","Qi J","Eisinger-Mathason TSK","Egolf S","Park PMC","Marino GE","Perry JA","Shah J","Rivera-Reyes A","Pak K","Grazioli A","Ye S","Chor S","Niedzwicki D","Lee AC","Alam MZ"],"additional_accession":[]},"is_claimable":false,"name":"YAP1-Mediated Suppression of USP31 Enhances NFκB Activity to Promote Sarcomagenesis.","description":"To date, no consistent oncogenic driver mutations have been identified in most adult soft tissue sarcomas; these tumors are thus generally insensitive to existing targeted therapies. Here we investigated alternate mechanisms underlying sarcomagenesis to identify potential therapeutic interventions. Undifferentiated pleomorphic sarcoma (UPS) is an aggressive tumor frequently found in skeletal muscle where deregulation of the Hippo pathway and aberrant stabilization of its transcriptional effector yes-associated protein 1 (YAP1) increases proliferation and tumorigenesis. However, the downstream mechanisms driving this deregulation are incompletely understood. Using autochthonous mouse models and whole genome analyses, we found that YAP1 was constitutively active in some sarcomas due to epige","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 May","modification":"2026-05-07T04:38:26.259Z","creation":"2019-06-06T23:04:39Z"},"accession":"S-EPMC6314302","cross_references":{"pubmed":["29490948"],"doi":["10.1158/0008-5472.CAN-17-4052","10.1158/0008-5472.can-17-4052"]}}