{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hasan R"],"funding":["University Grants Commission"],"pagination":["11"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6314952"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(1)"],"pubmed_abstract":["The present study was conducted to determine the prognostic significance of I655V SNP (rs1136201) is a genetic one in HER-2 oncoprotein in cases of colorectal cancer (CRC). We conducted a case-control study analysing 83 subjects (naïve primary CRC cases) who underwent CRC biopsy/colectomy and included 57 healthy control subjects. Analysis of HER-2 polymorphism was done by PCR-RFLP technique. The mean age was found to be 55.9 years; median age was 56 years and mode age was 54 years with a range of 43 (30-73). Males constitute 63 (75.9%) and females constitute 20 (24.1%) of patient population. According to gradewise distribution, 12 (14.45%) patients were of Grade I, 53 (63.85%) of Grade II, and 18 (21.68%) were of Grade III. We found out that out of 83 patients, 52 (62.65%) were of homozygo"],"journal":["3 Biotech"],"pubmed_title":["Frequency of I655V SNP of HER-2/<i>neu</i> in colorectal cancer: a study from India."],"pmcid":["PMC6314952"],"funding_grant_id":["F. No. 43-84/2014(SR) dated 23rd Sept. 2015"],"pubmed_authors":["Hasan R","Bharti PS","Khan V","Verma AK","Dev K","Anees A","Bhatt D","Khan S"],"additional_accession":[]},"is_claimable":false,"name":"Frequency of I655V SNP of HER-2/<i>neu</i> in colorectal cancer: a study from India.","description":"The present study was conducted to determine the prognostic significance of I655V SNP (rs1136201) is a genetic one in HER-2 oncoprotein in cases of colorectal cancer (CRC). We conducted a case-control study analysing 83 subjects (naïve primary CRC cases) who underwent CRC biopsy/colectomy and included 57 healthy control subjects. Analysis of HER-2 polymorphism was done by PCR-RFLP technique. The mean age was found to be 55.9 years; median age was 56 years and mode age was 54 years with a range of 43 (30-73). Males constitute 63 (75.9%) and females constitute 20 (24.1%) of patient population. According to gradewise distribution, 12 (14.45%) patients were of Grade I, 53 (63.85%) of Grade II, and 18 (21.68%) were of Grade III. We found out that out of 83 patients, 52 (62.65%) were of homozygo","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Jan","modification":"2025-06-01T03:42:53.292Z","creation":"2025-06-01T03:42:53.292Z"},"accession":"S-EPMC6314952","cross_references":{"pubmed":["30622849"],"doi":["10.1007/s13205-018-1545-z"]}}