biostudies-literatureHasan RUniversity Grants Commission11https://www.ebi.ac.uk/biostudies/studies/S-EPMC6314952biostudies-literatureUnknown9(1)The present study was conducted to determine the prognostic significance of I655V SNP (rs1136201) is a genetic one in HER-2 oncoprotein in cases of colorectal cancer (CRC). We conducted a case-control study analysing 83 subjects (naïve primary CRC cases) who underwent CRC biopsy/colectomy and included 57 healthy control subjects. Analysis of HER-2 polymorphism was done by PCR-RFLP technique. The mean age was found to be 55.9 years; median age was 56 years and mode age was 54 years with a range of 43 (30-73). Males constitute 63 (75.9%) and females constitute 20 (24.1%) of patient population. According to gradewise distribution, 12 (14.45%) patients were of Grade I, 53 (63.85%) of Grade II, and 18 (21.68%) were of Grade III. We found out that out of 83 patients, 52 (62.65%) were of homozygo3 BiotechFrequency of I655V SNP of HER-2/<i>neu</i> in colorectal cancer: a study from India.PMC6314952F. No. 43-84/2014(SR) dated 23rd Sept. 2015Hasan RBharti PSKhan VVerma AKDev KAnees ABhatt DKhan SfalseFrequency of I655V SNP of HER-2/<i>neu</i> in colorectal cancer: a study from India.The present study was conducted to determine the prognostic significance of I655V SNP (rs1136201) is a genetic one in HER-2 oncoprotein in cases of colorectal cancer (CRC). We conducted a case-control study analysing 83 subjects (naïve primary CRC cases) who underwent CRC biopsy/colectomy and included 57 healthy control subjects. Analysis of HER-2 polymorphism was done by PCR-RFLP technique. The mean age was found to be 55.9 years; median age was 56 years and mode age was 54 years with a range of 43 (30-73). Males constitute 63 (75.9%) and females constitute 20 (24.1%) of patient population. According to gradewise distribution, 12 (14.45%) patients were of Grade I, 53 (63.85%) of Grade II, and 18 (21.68%) were of Grade III. We found out that out of 83 patients, 52 (62.65%) were of homozygo2019-01-01T00:00:00Z2019 Jan2025-06-01T03:42:53.292Z2025-06-01T03:42:53.292ZS-EPMC63149523062284910.1007/s13205-018-1545-z