{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Peng A"],"funding":["Natural Science Foundation of Shandong Province","National Natural Science Foundation of China"],"pagination":["E470"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6315490"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(12)"],"pubmed_abstract":["Four angucycline glycosides including three new compounds landomycin N (<b>1</b>), galtamycin C (<b>2</b>) and vineomycin D (<b>3</b>), and a known homologue saquayamycin B (<b>4</b>), along with two alkaloids 1-acetyl-β-carboline (<b>5</b>) and indole-3-acetic acid (<b>6</b>), were isolated from the fermentation broth of an intertidal sediments-derived <i>Streptomyces</i> sp. Their structures were established by IR, HR-ESI-MS, 1D and 2D NMR techniques. Among the isolated angucyclines, saquayamycin B (<b>4</b>) displayed potent cytotoxic activity against hepatoma carcinoma cells HepG-2, SMMC-7721 and plc-prf-5, with IC<sub>50</sub> values 0.135, 0.033 and 0.244 μM respectively, superior to doxorubicin. Saquayamycin B (<b>4</b>) also induced apoptosis in SMMC-7721 cells as detected by its m"],"journal":["Marine drugs"],"pubmed_title":["Angucycline Glycosides from an Intertidal Sediments Strain <i>Streptomyces</i> sp. and Their Cytotoxic Activity against Hepatoma Carcinoma Cells."],"pmcid":["PMC6315490"],"funding_grant_id":["ZR2014HM018","81872771"],"pubmed_authors":["Li X","Xie W","Li E","Peng A","Qu X","Liu F"],"additional_accession":[]},"is_claimable":false,"name":"Angucycline Glycosides from an Intertidal Sediments Strain <i>Streptomyces</i> sp. and Their Cytotoxic Activity against Hepatoma Carcinoma Cells.","description":"Four angucycline glycosides including three new compounds landomycin N (<b>1</b>), galtamycin C (<b>2</b>) and vineomycin D (<b>3</b>), and a known homologue saquayamycin B (<b>4</b>), along with two alkaloids 1-acetyl-β-carboline (<b>5</b>) and indole-3-acetic acid (<b>6</b>), were isolated from the fermentation broth of an intertidal sediments-derived <i>Streptomyces</i> sp. Their structures were established by IR, HR-ESI-MS, 1D and 2D NMR techniques. Among the isolated angucyclines, saquayamycin B (<b>4</b>) displayed potent cytotoxic activity against hepatoma carcinoma cells HepG-2, SMMC-7721 and plc-prf-5, with IC<sub>50</sub> values 0.135, 0.033 and 0.244 μM respectively, superior to doxorubicin. Saquayamycin B (<b>4</b>) also induced apoptosis in SMMC-7721 cells as detected by its m","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Nov","modification":"2026-04-13T23:07:51.467Z","creation":"2019-03-26T22:36:49Z"},"accession":"S-EPMC6315490","cross_references":{"pubmed":["30486371"],"doi":["10.3390/md16120470"]}}