biostudies-literaturePeng ANatural Science Foundation of Shandong ProvinceNational Natural Science Foundation of ChinaE470https://www.ebi.ac.uk/biostudies/studies/S-EPMC6315490biostudies-literatureUnknown16(12)Four angucycline glycosides including three new compounds landomycin N (<b>1</b>), galtamycin C (<b>2</b>) and vineomycin D (<b>3</b>), and a known homologue saquayamycin B (<b>4</b>), along with two alkaloids 1-acetyl-β-carboline (<b>5</b>) and indole-3-acetic acid (<b>6</b>), were isolated from the fermentation broth of an intertidal sediments-derived <i>Streptomyces</i> sp. Their structures were established by IR, HR-ESI-MS, 1D and 2D NMR techniques. Among the isolated angucyclines, saquayamycin B (<b>4</b>) displayed potent cytotoxic activity against hepatoma carcinoma cells HepG-2, SMMC-7721 and plc-prf-5, with IC₅₀ values 0.135, 0.033 and 0.244 μM respectively, superior to doxorubicin. Saquayamycin B (<b>4</b>) also induced apoptosis in SMMC-7721 cells as detected by its mMarine drugsAngucycline Glycosides from an Intertidal Sediments Strain <i>Streptomyces</i> sp. and Their Cytotoxic Activity against Hepatoma Carcinoma Cells.PMC6315490ZR2014HM01881872771Li XXie WLi EPeng AQu XLiu FfalseAngucycline Glycosides from an Intertidal Sediments Strain <i>Streptomyces</i> sp. and Their Cytotoxic Activity against Hepatoma Carcinoma Cells.Four angucycline glycosides including three new compounds landomycin N (<b>1</b>), galtamycin C (<b>2</b>) and vineomycin D (<b>3</b>), and a known homologue saquayamycin B (<b>4</b>), along with two alkaloids 1-acetyl-β-carboline (<b>5</b>) and indole-3-acetic acid (<b>6</b>), were isolated from the fermentation broth of an intertidal sediments-derived <i>Streptomyces</i> sp. Their structures were established by IR, HR-ESI-MS, 1D and 2D NMR techniques. Among the isolated angucyclines, saquayamycin B (<b>4</b>) displayed potent cytotoxic activity against hepatoma carcinoma cells HepG-2, SMMC-7721 and plc-prf-5, with IC₅₀ values 0.135, 0.033 and 0.244 μM respectively, superior to doxorubicin. Saquayamycin B (<b>4</b>) also induced apoptosis in SMMC-7721 cells as detected by its m2018-01-01T00:00:00Z2018 Nov2026-04-13T23:07:51.467Z2019-03-26T22:36:49ZS-EPMC63154903048637110.3390/md16120470