biostudies-literatureLiu HWChi-Tai YehE491https://www.ebi.ac.uk/biostudies/studies/S-EPMC6315804biostudies-literatureUnknown10(12)<h4>Background</h4>Glioblastoma (GBM), a malignant form of glioma, is characterized by resistance to therapy and poor prognosis. Accumulating evidence shows that the initiation, propagation, and recurrence of GBM is attributable to the presence of GBM stem cells (GBM-CSCs).<h4>Experimental approach</h4>Herein, we investigated the effect of 4-Acetylantroquinonol B (4-AAQB), a bioactive isolate of <i>Antrodia cinnamomea</i>, on GBM cell viability, oncogenic, and CSCs-like activities.<h4>Results</h4>We observed that aberrant expression of catenin is characteristic of GBM, compared to other glioma types (<i>p</i> = 0.0001, log-rank test = 475.2), and correlates with poor prognosis of GBM patients. Lower grade glioma and glioblastoma patients (<i>n</i> = 1152) with low catenin expression had 25CancersThe Disruption of the β-Catenin/TCF-1/STAT3 Signaling Axis by 4-Acetylantroquinonol B Inhibits the Tumorigenesis and Cancer Stem-Cell-Like Properties of Glioblastoma Cells, In Vitro and In Vivo.PMC6315804TMU-NTUST-103-03Hueng DYHuang CCLin CMSu YKLiu HWDeng LHsiao MLee WHChien MHYeh CTBamodu OAfalseThe Disruption of the β-Catenin/TCF-1/STAT3 Signaling Axis by 4-Acetylantroquinonol B Inhibits the Tumorigenesis and Cancer Stem-Cell-Like Properties of Glioblastoma Cells, In Vitro and In Vivo.<h4>Background</h4>Glioblastoma (GBM), a malignant form of glioma, is characterized by resistance to therapy and poor prognosis. Accumulating evidence shows that the initiation, propagation, and recurrence of GBM is attributable to the presence of GBM stem cells (GBM-CSCs).<h4>Experimental approach</h4>Herein, we investigated the effect of 4-Acetylantroquinonol B (4-AAQB), a bioactive isolate of <i>Antrodia cinnamomea</i>, on GBM cell viability, oncogenic, and CSCs-like activities.<h4>Results</h4>We observed that aberrant expression of catenin is characteristic of GBM, compared to other glioma types (<i>p</i> = 0.0001, log-rank test = 475.2), and correlates with poor prognosis of GBM patients. Lower grade glioma and glioblastoma patients (<i>n</i> = 1152) with low catenin expression had 252018-01-01T00:00:00Z2018 Dec2026-04-13T23:11:10.827Z2019-03-26T22:36:04ZS-EPMC63158043056309410.3390/cancers10120491