{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lin W"],"funding":["Earmarked Fund for China Agriculture Research System","Fundamental Research Funds for the Central Universities","National Natural Science Foundation of China"],"pagination":["E512"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6315824"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(12)"],"pubmed_abstract":["Hazardous contaminants, such as nitrite and microcystin-leucine arginine (MC-LR), are released into water bodies during cyanobacterial blooms and may adversely influence the normal physiological function of hydrobiontes. The combined effects of nitrite and MC-LR on the antioxidant defense and innate immunity were evaluated through an orthogonal experimental design (nitrite: 0, 29, 290 μM; MC-LR: 0, 3, 30 nM). Remarkable increases in malondialdehyde (MDA) levels have suggested that nitrite and/or MC-LR exposures induce oxidative stress in fish spleen, which were indirectly confirmed by significant downregulations of total antioxidant capacity (T-AOC), glutathione (GSH) contents, as well as transcriptional levels of antioxidant enzyme genes cat1, sod1 and gpx1a. Simultaneously, nitrite and M"],"journal":["Toxins"],"pubmed_title":["Nitrite Enhances MC-LR-Induced Changes on Splenic Oxidation Resistance and Innate Immunity in Male Zebrafish."],"pmcid":["PMC6315824"],"funding_grant_id":["2662015PY012","31670521","CARS-46","2662015PY119"],"pubmed_authors":["Zhang D","Li D","Guo H","Lin W","Tang R","Li L","Wang L","Wu X"],"additional_accession":[]},"is_claimable":false,"name":"Nitrite Enhances MC-LR-Induced Changes on Splenic Oxidation Resistance and Innate Immunity in Male Zebrafish.","description":"Hazardous contaminants, such as nitrite and microcystin-leucine arginine (MC-LR), are released into water bodies during cyanobacterial blooms and may adversely influence the normal physiological function of hydrobiontes. The combined effects of nitrite and MC-LR on the antioxidant defense and innate immunity were evaluated through an orthogonal experimental design (nitrite: 0, 29, 290 μM; MC-LR: 0, 3, 30 nM). Remarkable increases in malondialdehyde (MDA) levels have suggested that nitrite and/or MC-LR exposures induce oxidative stress in fish spleen, which were indirectly confirmed by significant downregulations of total antioxidant capacity (T-AOC), glutathione (GSH) contents, as well as transcriptional levels of antioxidant enzyme genes cat1, sod1 and gpx1a. Simultaneously, nitrite and M","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Dec","modification":"2026-05-07T05:29:32.878Z","creation":"2019-03-26T22:36:04Z"},"accession":"S-EPMC6315824","cross_references":{"pubmed":["30513985"],"doi":["10.3390/toxins10120512"]}}