{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Muller DC"],"funding":["Cancer Research UK","NHLBI NIH HHS","NCI NIH HHS"],"pagination":["k4981"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6315896"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["364"],"pubmed_abstract":["<h4>Objectives</h4>To conduct a comprehensive analysis of prospectively measured circulating high sensitivity C reactive protein (hsCRP) concentration and risk of lung cancer overall, by smoking status (never, former, and current smokers), and histological sub-type.<h4>Design</h4>Nested case-control study.<h4>Setting</h4>20 population based cohort studies in Asia, Europe, Australia, and the United States.<h4>Participants</h4>5299 patients with incident lung cancer, with individually incidence density matched controls.<h4>Exposure</h4>Circulating hsCRP concentrations in prediagnostic serum or plasma samples.<h4>Main outcome measure</h4>Incident lung cancer diagnosis.<h4>Results</h4>A positive association between circulating hsCRP concentration and the risk of lung cancer for current (odds r"],"journal":["BMJ (Clinical research ed.)"],"pubmed_title":["Circulating high sensitivity C reactive protein concentrations and risk of lung cancer: nested case-control study within Lung Cancer Cohort Consortium."],"pmcid":["PMC6315896"],"funding_grant_id":["24390","UM1 CA182910","U01 CA164973","UM1 CA182934","HHSN268201600002C","U01 CA155340","UM1 CA173640","HHSN268201600003C","HHSN268201600001C","HHSN268201600018C","HHSN268201600004C"],"pubmed_authors":["Hodge A","Cai Q","Sesso HD","Thomson CA","Severi G","Guida F","Hoffman Bolton J","Le Marchand L","Weinstein SJ","Ueland PM","Hveem K","Koh WP","Visvanathan K","Langhammer A","Grankvist K","Giles GG","Caporaso NE","Midttun O","Zeleniuch-Jacquotte A","Engstrom G","Yuan JM","Larose TL","Brennan P","Milne RL","Muller DC","Brunnstrom H","Buring JE","Shu XO","Meyer K","Purdue MP","Stampfer MJ","Zheng W","Arslan AA","Albanes D","Lee IM","Prentice RL","Zhang X","Xiang YB","Stevens VL","Johansson M","Gaziano JM","Han J","Blot WJ","Pettinger M"],"additional_accession":[]},"is_claimable":false,"name":"Circulating high sensitivity C reactive protein concentrations and risk of lung cancer: nested case-control study within Lung Cancer Cohort Consortium.","description":"<h4>Objectives</h4>To conduct a comprehensive analysis of prospectively measured circulating high sensitivity C reactive protein (hsCRP) concentration and risk of lung cancer overall, by smoking status (never, former, and current smokers), and histological sub-type.<h4>Design</h4>Nested case-control study.<h4>Setting</h4>20 population based cohort studies in Asia, Europe, Australia, and the United States.<h4>Participants</h4>5299 patients with incident lung cancer, with individually incidence density matched controls.<h4>Exposure</h4>Circulating hsCRP concentrations in prediagnostic serum or plasma samples.<h4>Main outcome measure</h4>Incident lung cancer diagnosis.<h4>Results</h4>A positive association between circulating hsCRP concentration and the risk of lung cancer for current (odds r","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Jan","modification":"2025-04-04T12:41:48.575Z","creation":"2019-03-26T22:36:50Z"},"accession":"S-EPMC6315896","cross_references":{"pubmed":["30606716"],"doi":["10.1136/bmj.k4981"]}}