biostudies-literatureMuller DCCancer Research UKNHLBI NIH HHSNCI NIH HHSk4981https://www.ebi.ac.uk/biostudies/studies/S-EPMC6315896biostudies-literatureUnknown364<h4>Objectives</h4>To conduct a comprehensive analysis of prospectively measured circulating high sensitivity C reactive protein (hsCRP) concentration and risk of lung cancer overall, by smoking status (never, former, and current smokers), and histological sub-type.<h4>Design</h4>Nested case-control study.<h4>Setting</h4>20 population based cohort studies in Asia, Europe, Australia, and the United States.<h4>Participants</h4>5299 patients with incident lung cancer, with individually incidence density matched controls.<h4>Exposure</h4>Circulating hsCRP concentrations in prediagnostic serum or plasma samples.<h4>Main outcome measure</h4>Incident lung cancer diagnosis.<h4>Results</h4>A positive association between circulating hsCRP concentration and the risk of lung cancer for current (odds rBMJ (Clinical research ed.)Circulating high sensitivity C reactive protein concentrations and risk of lung cancer: nested case-control study within Lung Cancer Cohort Consortium.PMC631589624390UM1 CA182910U01 CA164973UM1 CA182934HHSN268201600002CU01 CA155340UM1 CA173640HHSN268201600003CHHSN268201600001CHHSN268201600018CHHSN268201600004CHodge ACai QSesso HDThomson CASeveri GGuida FHoffman Bolton JLe Marchand LWeinstein SJUeland PMHveem KKoh WPVisvanathan KLanghammer AGrankvist KGiles GGCaporaso NEMidttun OZeleniuch-Jacquotte AEngstrom GYuan JMLarose TLBrennan PMilne RLMuller DCBrunnstrom HBuring JEShu XOMeyer KPurdue MPStampfer MJZheng WArslan AAAlbanes DLee IMPrentice RLZhang XXiang YBStevens VLJohansson MGaziano JMHan JBlot WJPettinger MfalseCirculating high sensitivity C reactive protein concentrations and risk of lung cancer: nested case-control study within Lung Cancer Cohort Consortium.<h4>Objectives</h4>To conduct a comprehensive analysis of prospectively measured circulating high sensitivity C reactive protein (hsCRP) concentration and risk of lung cancer overall, by smoking status (never, former, and current smokers), and histological sub-type.<h4>Design</h4>Nested case-control study.<h4>Setting</h4>20 population based cohort studies in Asia, Europe, Australia, and the United States.<h4>Participants</h4>5299 patients with incident lung cancer, with individually incidence density matched controls.<h4>Exposure</h4>Circulating hsCRP concentrations in prediagnostic serum or plasma samples.<h4>Main outcome measure</h4>Incident lung cancer diagnosis.<h4>Results</h4>A positive association between circulating hsCRP concentration and the risk of lung cancer for current (odds r2019-01-01T00:00:00Z2019 Jan2025-04-04T12:41:48.575Z2019-03-26T22:36:50ZS-EPMC63158963060671610.1136/bmj.k4981