biostudies-literatureTran-Lam TTVAST.TĐ.TP/16-18E69https://www.ebi.ac.uk/biostudies/studies/S-EPMC6316763biostudies-literatureUnknown6(4)A novel method was developed for the sensitive, cheap and fast quantitation of 10 phthalates in non-alcoholic beverages by liquid⁻liquid extraction (LLE) combined with gas chromatography tandem mass spectrometry (GC-MS/MS). The best results were obtained when <i>n</i>-hexane was used as extraction solvent. A central composite design (CCD) was applied to select the most appreciated operating condition. The method performance was evaluated according to the SANTE/11945/2015 guidelines and was linear in the 0.1 to 200 µg/L range for 10 phthalate compounds, with <i>r</i>² > 0.996 and individual residuals <15%. Repeatability (RSD_r), within-laboratory reproducibility (RSD_wr), and the trueness range were from 2.7 to 9.1%, from 3.4 to 14.3% and from 91.5 to 118.1%, respectivelToxicsOptimization of Sample Preparation for Detection of 10 Phthalates in Non-Alcoholic Beverages in Northern Vietnam.PMC6316763VAST.TĐ.TP.03/16-18Nguyen DTMa HKLe GTTran-Lam TTPham TQDao YHfalseOptimization of Sample Preparation for Detection of 10 Phthalates in Non-Alcoholic Beverages in Northern Vietnam.A novel method was developed for the sensitive, cheap and fast quantitation of 10 phthalates in non-alcoholic beverages by liquid⁻liquid extraction (LLE) combined with gas chromatography tandem mass spectrometry (GC-MS/MS). The best results were obtained when <i>n</i>-hexane was used as extraction solvent. A central composite design (CCD) was applied to select the most appreciated operating condition. The method performance was evaluated according to the SANTE/11945/2015 guidelines and was linear in the 0.1 to 200 µg/L range for 10 phthalate compounds, with <i>r</i>² > 0.996 and individual residuals <15%. Repeatability (RSD_r), within-laboratory reproducibility (RSD_wr), and the trueness range were from 2.7 to 9.1%, from 3.4 to 14.3% and from 91.5 to 118.1%, respectivel2018-01-01T00:00:00Z2018 Nov2026-07-16T16:37:14.153Z2019-03-26T22:36:08ZS-EPMC63167633046324110.3390/toxics6040069