biostudies-literatureRajarajan PNIMH NIH HHS21-40https://www.ebi.ac.uk/biostudies/studies/S-EPMC6318347biostudies-literatureUnknown157Chromosomal conformations, including promoter-enhancer loops, provide a critical regulatory layer for the transcriptional machinery. Therefore, schizophrenia, a common psychiatric disorder associated with broad changes in neuronal gene expression in prefrontal cortex and other brain regions implicated in psychosis, could be associated with alterations in higher-order chromatin. Here, we review early studies on spatial genome organization in the schizophrenia postmortem brain and discuss how integrative approaches using cell culture and animal model systems could gain deeper insight into the potential roles of higher-order chromatin for the neurobiology of and novel treatment avenues for common psychiatric disease.Progress in molecular biology and translational scienceChromosomal Conformations and Epigenomic Regulation in Schizophrenia.PMC6318347F30 MH113330Jiang YKassim BSAkbarian SRajarajan PfalseChromosomal Conformations and Epigenomic Regulation in Schizophrenia.Chromosomal conformations, including promoter-enhancer loops, provide a critical regulatory layer for the transcriptional machinery. Therefore, schizophrenia, a common psychiatric disorder associated with broad changes in neuronal gene expression in prefrontal cortex and other brain regions implicated in psychosis, could be associated with alterations in higher-order chromatin. Here, we review early studies on spatial genome organization in the schizophrenia postmortem brain and discuss how integrative approaches using cell culture and animal model systems could gain deeper insight into the potential roles of higher-order chromatin for the neurobiology of and novel treatment avenues for common psychiatric disease.2018-01-01T00:00:00Z20182025-04-21T16:20:41.79Z2019-03-26T22:34:00ZS-EPMC63183472993395110.1016/bs.pmbts.2017.11.022