biostudies-literatureUnknown14(1)Strada LJanssen-Cilag GmbH<h4>Background</h4>Knowledge of health-related quality of life (HRQOL) of patients receiving opioid substitution treatment (OST) is limited and fragmented. The present study examines the HRQOL of a large national sample of OST patients in Germany and sociodemographic and clinical correlates.<h4>Methods</h4>Cross-sectional data on the HRQOL of 2176 OST patients was compared with German general population norms. Patients were recruited from 63 OST practices across Germany. To identify correlates of HRQOL, as measured with the SF-12, we performed bi- and multivariate analyses with sociodemographic and clinical variables, including patient- and clinician-reported outcomes on physical and mental health.<h4>Results</h4>Patients' HRQOL was significantly poorer than in the general population, espeSubstance abuse treatment, prevention, and policy2https://www.ebi.ac.uk/biostudies/studies/S-EPMC6318871biostudies-literatureFactors associated with health-related quality of life in a large national sample of patients receiving opioid substitution treatment in Germany: A cross-sectional study.PMC6318871Verthein UScherbaum NSchmidt CSRosenkranz MSchulte BStrada LReimer JfalseFactors associated with health-related quality of life in a large national sample of patients receiving opioid substitution treatment in Germany: A cross-sectional study.<h4>Background</h4>Knowledge of health-related quality of life (HRQOL) of patients receiving opioid substitution treatment (OST) is limited and fragmented. The present study examines the HRQOL of a large national sample of OST patients in Germany and sociodemographic and clinical correlates.<h4>Methods</h4>Cross-sectional data on the HRQOL of 2176 OST patients was compared with German general population norms. Patients were recruited from 63 OST practices across Germany. To identify correlates of HRQOL, as measured with the SF-12, we performed bi- and multivariate analyses with sociodemographic and clinical variables, including patient- and clinician-reported outcomes on physical and mental health.<h4>Results</h4>Patients' HRQOL was significantly poorer than in the general population, espe2019-01-01T00:00:00Z2019 Jan2025-04-22T07:28:23.665Z2019-03-26T22:36:10ZS-EPMC63188713060618810.1186/s13011-018-0187-9