{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["9(97)"],"submitter":["Ahlmanner F"],"pubmed_abstract":["Increasing knowledge of the function and regulation of tumor-infiltrating lymphocytes has led to new insights in cancer immunotherapy. Regulatory T cells (Treg) accumulate in colon tumors, and we recently showed that CD39<sup>+</sup> Treg from cancer patients inhibit transendothelial migration of conventional T cells. CD39 mediates the hydrolysis of ATP to immunosuppressive adenosine and adds to the immunosuppressive effects of Treg. Here, we further investigated the regulatory features of intratumoral CD39<sup>+</sup> Treg in colon cancer. Using flow cytometry analyses of cells from 46 colon cancer patients, we confirm the accumulation of CD39<sup>+</sup> Treg in the tumor tissue compared to unaffected colon tissue, and also show that tumor-infiltrating Treg express more CD39 and Foxp3 on"],"journal":["Oncotarget"],"pagination":["36993-37007"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6319332"],"repository":["biostudies-literature"],"pubmed_title":["CD39<sup>+</sup> regulatory T cells accumulate in colon adenocarcinomas and display markers of increased suppressive function."],"pmcid":["PMC6319332"],"pubmed_authors":["Borjesson L","Gustavsson B","Akeus P","Ahlmanner F","Quiding-Jarbrink M","Sundstrom P","Lindskog EB","Eklof J","Raghavan S"],"additional_accession":[]},"is_claimable":false,"name":"CD39<sup>+</sup> regulatory T cells accumulate in colon adenocarcinomas and display markers of increased suppressive function.","description":"Increasing knowledge of the function and regulation of tumor-infiltrating lymphocytes has led to new insights in cancer immunotherapy. Regulatory T cells (Treg) accumulate in colon tumors, and we recently showed that CD39<sup>+</sup> Treg from cancer patients inhibit transendothelial migration of conventional T cells. CD39 mediates the hydrolysis of ATP to immunosuppressive adenosine and adds to the immunosuppressive effects of Treg. Here, we further investigated the regulatory features of intratumoral CD39<sup>+</sup> Treg in colon cancer. Using flow cytometry analyses of cells from 46 colon cancer patients, we confirm the accumulation of CD39<sup>+</sup> Treg in the tumor tissue compared to unaffected colon tissue, and also show that tumor-infiltrating Treg express more CD39 and Foxp3 on","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Dec","modification":"2025-04-18T14:30:00.385Z","creation":"2019-03-26T22:37:34Z"},"accession":"S-EPMC6319332","cross_references":{"pubmed":["30651930"],"doi":["10.18632/oncotarget.26435"]}}