{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Levi SM"],"funding":["HHS | National Institutes of Health","NIGMS NIH HHS","National Science Foundation"],"pagination":["35-39"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6320501"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["116(1)"],"pubmed_abstract":["Glycosyl phosphates are shown to be activated to stereospecific nucleophilic substitution reactions by precisely tailored bis-thiourea catalysts. Enhanced reactivity and scope is observed with phosphate relative to chloride leaving groups. Stronger binding (Km) to the H-bond donor and enhanced reactivity of the complex (kcat) enables efficient catalysis with broad functional group compatibility under mild, neutral conditions."],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pubmed_title":["Catalytic activation of glycosyl phosphates for stereoselective coupling reactions."],"pmcid":["PMC6320501"],"funding_grant_id":["GM43214","U01 GM116249","2015412210","R37 GM043214","GM116249","R01 GM043214"],"pubmed_authors":["Jacobsen EN","Li Q","Levi SM","Rotheli AR"],"additional_accession":[]},"is_claimable":false,"name":"Catalytic activation of glycosyl phosphates for stereoselective coupling reactions.","description":"Glycosyl phosphates are shown to be activated to stereospecific nucleophilic substitution reactions by precisely tailored bis-thiourea catalysts. Enhanced reactivity and scope is observed with phosphate relative to chloride leaving groups. Stronger binding (Km) to the H-bond donor and enhanced reactivity of the complex (kcat) enables efficient catalysis with broad functional group compatibility under mild, neutral conditions.","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Jan","modification":"2025-04-04T22:31:23.613Z","creation":"2019-08-12T07:01:47Z"},"accession":"S-EPMC6320501","cross_references":{"pubmed":["30559190"],"doi":["10.1073/pnas.1811186116"]}}