{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["19(12)"],"submitter":["Preiano M"],"pubmed_abstract":["<h4>Background</h4>Antimicrobial peptides (AMP) play a pivotal role in innate host defense and in immune response. The delineation of new MS-based profiling tools, which are able to produce panels of AMP of the nasal fluid (NF), may be attractive for the discovery of new potential diagnostic markers of respiratory disorders.<h4>Methods</h4>Swabs collected NF from healthy patients and from patients with respiratory disorders. We used a fast procedure based on mesoporous silica particles (MPS) to enrich NF in its AMP component in combination with MALDI-TOF/TOF MS as a key tool for rapidly analyzing clinical samples.<h4>Results</h4>Reproducible MS peptide fingerprints were generated for each subject and several AMP were detected including (Human Neutrophil Peptides) HNPs, Statherin, Thymosin-"],"journal":["International journal of molecular sciences"],"pagination":["E4005"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6320778"],"repository":["biostudies-literature"],"pubmed_title":["Rapid Detection and Identification of Antimicrobial Peptide Fingerprints of Nasal Fluid by Mesoporous Silica Particles and MALDI-TOF/TOF Mass Spectrometry: From the Analytical Approach to the Diagnostic Applicability in Precision Medicine."],"pmcid":["PMC6320778"],"pubmed_authors":["Savino R","Pelaia C","Fregola A","Murfuni MS","Terracciano R","Villella C","Colica C","Lombardo N","Preiano M","Maggisano G","Pelaia G"],"additional_accession":[]},"is_claimable":false,"name":"Rapid Detection and Identification of Antimicrobial Peptide Fingerprints of Nasal Fluid by Mesoporous Silica Particles and MALDI-TOF/TOF Mass Spectrometry: From the Analytical Approach to the Diagnostic Applicability in Precision Medicine.","description":"<h4>Background</h4>Antimicrobial peptides (AMP) play a pivotal role in innate host defense and in immune response. The delineation of new MS-based profiling tools, which are able to produce panels of AMP of the nasal fluid (NF), may be attractive for the discovery of new potential diagnostic markers of respiratory disorders.<h4>Methods</h4>Swabs collected NF from healthy patients and from patients with respiratory disorders. We used a fast procedure based on mesoporous silica particles (MPS) to enrich NF in its AMP component in combination with MALDI-TOF/TOF MS as a key tool for rapidly analyzing clinical samples.<h4>Results</h4>Reproducible MS peptide fingerprints were generated for each subject and several AMP were detected including (Human Neutrophil Peptides) HNPs, Statherin, Thymosin-","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Dec","modification":"2026-04-29T16:08:57.573Z","creation":"2019-03-26T22:30:02Z"},"accession":"S-EPMC6320778","cross_references":{"pubmed":["30545076"],"doi":["10.3390/ijms19124005"]}}