{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["19(12)"],"submitter":["Mochizuki D"],"pubmed_abstract":["Enhancer of Zeste homologue 2 (EZH2) overexpression is associated with tumor proliferation, metastasis, and poor prognosis. Targeting and inhibition of EZH2 is a potentially effective therapeutic strategy for head and neck squamous cell carcinoma (HNSCC). We analyzed EZH2 mRNA expression in a well-characterized dataset of 230 (110 original and 120 validation cohorts) human head and neck cancer samples. This study aimed to investigate the effects of inhibiting EZH2, either via RNA interference or via pharmacotherapy, on HNSCC growth. EZH2 upregulation was significantly correlated with recurrence (p < 0.001) and the methylation index of tumor suppressor genes (p < 0.05). DNMT3A was significantly upregulated upon EZH2 upregulation (p = 0.043). Univariate analysis revealed that EZH2 upregulati"],"journal":["International journal of molecular sciences"],"pagination":["E3707"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6320890"],"repository":["biostudies-literature"],"pubmed_title":["Aberrant Epigenetic Regulation in Head and Neck Cancer Due to Distinct EZH2 Overexpression and DNA Hypermethylation."],"pmcid":["PMC6320890"],"pubmed_authors":["Imai A","Mima M","Kanazawa T","Kawasaki H","Yamada S","Misawa Y","Nakagawa T","Misawa K","Mochizuki D","Endo S"],"additional_accession":[]},"is_claimable":false,"name":"Aberrant Epigenetic Regulation in Head and Neck Cancer Due to Distinct EZH2 Overexpression and DNA Hypermethylation.","description":"Enhancer of Zeste homologue 2 (EZH2) overexpression is associated with tumor proliferation, metastasis, and poor prognosis. Targeting and inhibition of EZH2 is a potentially effective therapeutic strategy for head and neck squamous cell carcinoma (HNSCC). We analyzed EZH2 mRNA expression in a well-characterized dataset of 230 (110 original and 120 validation cohorts) human head and neck cancer samples. This study aimed to investigate the effects of inhibiting EZH2, either via RNA interference or via pharmacotherapy, on HNSCC growth. EZH2 upregulation was significantly correlated with recurrence (p < 0.001) and the methylation index of tumor suppressor genes (p < 0.05). DNMT3A was significantly upregulated upon EZH2 upregulation (p = 0.043). Univariate analysis revealed that EZH2 upregulati","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Nov","modification":"2025-04-26T10:34:24.586Z","creation":"2019-03-26T22:30:03Z"},"accession":"S-EPMC6320890","cross_references":{"pubmed":["30469511"],"doi":["10.3390/ijms19123707"]}}