{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Del Papa N"],"funding":["SIR, Società italiana Reumatologia"],"pagination":["7"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6322261"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["21(1)"],"pubmed_abstract":["<h4>Background</h4>A randomized controlled trial (RCT) was performed to confirm preliminary uncontrolled data indicating that regional adipose tissue (AT) grafting (G) is effective in inducing ischemic digital ulcer (IDU) healing in patients with systemic sclerosis (SSc).<h4>Patients and methods</h4>SSc patients with IDUs were randomized to be blindly treated with AT-G or a sham procedure (SP). AT-G consisted of injection, at the base of the finger with the IDU, of 0.5-1 ml AT after centrifugation of fat aspirate. The SP consisted of false liposuction and local injection of saline solution. The primary endpoint was to compare the cumulative prevalence of healed IDUs in the two groups within the following 8 weeks.<h4>Results</h4>AT-G and the SP were carried out in 25 and 13 patients, respec"],"journal":["Arthritis research & therapy"],"pubmed_title":["Regional grafting of autologous adipose tissue is effective in inducing prompt healing of indolent digital ulcers in patients with systemic sclerosis: results of a monocentric randomized controlled study."],"pmcid":["PMC6322261"],"funding_grant_id":["2015"],"pubmed_authors":["Del Papa N","Minniti A","Di Luca G","Maglione W","Andracco R","Zaccara E","Pignataro F","Vitali C"],"additional_accession":[]},"is_claimable":false,"name":"Regional grafting of autologous adipose tissue is effective in inducing prompt healing of indolent digital ulcers in patients with systemic sclerosis: results of a monocentric randomized controlled study.","description":"<h4>Background</h4>A randomized controlled trial (RCT) was performed to confirm preliminary uncontrolled data indicating that regional adipose tissue (AT) grafting (G) is effective in inducing ischemic digital ulcer (IDU) healing in patients with systemic sclerosis (SSc).<h4>Patients and methods</h4>SSc patients with IDUs were randomized to be blindly treated with AT-G or a sham procedure (SP). AT-G consisted of injection, at the base of the finger with the IDU, of 0.5-1 ml AT after centrifugation of fat aspirate. The SP consisted of false liposuction and local injection of saline solution. The primary endpoint was to compare the cumulative prevalence of healed IDUs in the two groups within the following 8 weeks.<h4>Results</h4>AT-G and the SP were carried out in 25 and 13 patients, respec","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Jan","modification":"2025-05-31T22:16:22.439Z","creation":"2025-05-31T22:16:22.439Z"},"accession":"S-EPMC6322261","cross_references":{"pubmed":["30616671"],"doi":["10.1186/s13075-018-1792-8"]}}