biostudies-literatureBenedictus LMinistry of Economic Affairs, Agriculture and Innovation of the Dutch government15https://www.ebi.ac.uk/biostudies/studies/S-EPMC6323680biostudies-literatureUnknown15(1)<h4>Background</h4>Staphylococcus aureus, a leading cause of mastitis in dairy cattle, causes severe mastitis and/or chronic persistent infections with detrimental effects on the cows' wellbeing, lifespan and milk production. Despite years of research there is no effective vaccine against S. aureus mastitis. Boosting of non-protective pre-existing immunity to S. aureus, induced by natural exposure to S. aureus, by vaccination may interfere with vaccine efficacy. The aim was to assess whether experimental immunization of S. aureus naïve animals results in an immune response that differs from immunity following natural exposure to S. aureus.<h4>Results</h4>First, to define the period during which calves are immunologically naïve for S. aureus, Efb, LukM, and whole-cell S. aureus specific serBMC veterinary researchImmunization of young heifers with staphylococcal immune evasion proteins before natural exposure to Staphylococcus aureus induces a humoral immune response in serum and milk.PMC6323680ALTANT EVAC2Daemen IKoets ARavesloot LBoerhout EEisenberg SBenedictus Lvan Strijp JPoppe KBroere FRutten VfalseImmunization of young heifers with staphylococcal immune evasion proteins before natural exposure to Staphylococcus aureus induces a humoral immune response in serum and milk.<h4>Background</h4>Staphylococcus aureus, a leading cause of mastitis in dairy cattle, causes severe mastitis and/or chronic persistent infections with detrimental effects on the cows' wellbeing, lifespan and milk production. Despite years of research there is no effective vaccine against S. aureus mastitis. Boosting of non-protective pre-existing immunity to S. aureus, induced by natural exposure to S. aureus, by vaccination may interfere with vaccine efficacy. The aim was to assess whether experimental immunization of S. aureus naïve animals results in an immune response that differs from immunity following natural exposure to S. aureus.<h4>Results</h4>First, to define the period during which calves are immunologically naïve for S. aureus, Efb, LukM, and whole-cell S. aureus specific ser2019-01-01T00:00:00Z2019 Jan2026-07-16T16:45:07.105Z2019-03-26T22:36:18ZS-EPMC63236803061660910.1186/s12917-018-1765-9