{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Dang Y"],"funding":["Science and Technology Commission of Shanghai Municipality","National Natural Science Foundation of China"],"pagination":["8"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6323852"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["19(1)"],"pubmed_abstract":["<h4>Background</h4>Ling-gui-zhu-gan decoction (LGZG), a classic traditional Chinese medicine formula, has been confirmed to be effective in improving steatosis in non-alcoholic fatty liver disease (NAFLD). However, the mechanism under the efficacy remains unclear. Hence, this study was designed to investigate the mechanisms of LGZG on alleviating steatosis.<h4>Methods</h4>Twenty four rats were randomly divided into three groups: normal group, NAFLD group, fed with high fat diet (HFD) and LGZG group (fed with HFD and supplemented with LGZG). After 4 weeks intervention, blood and liver were collected. Liver steatosis was detected by Oil Red O staining, and blood lipids were biochemically determined. Whole genome genes were detected by RNA-Seq and the significant different genes were verified"],"journal":["BMC complementary and alternative medicine"],"pubmed_title":["The traditional Chinese formulae Ling-gui-zhu-gan decoction alleviated non-alcoholic fatty liver disease via inhibiting PPP1R3C mediated molecules."],"pmcid":["PMC6323852"],"funding_grant_id":["18YF1423700","8161001158"],"pubmed_authors":["Ji G","Zhou W","Zhang L","Dang Y","Hao S"],"additional_accession":[]},"is_claimable":false,"name":"The traditional Chinese formulae Ling-gui-zhu-gan decoction alleviated non-alcoholic fatty liver disease via inhibiting PPP1R3C mediated molecules.","description":"<h4>Background</h4>Ling-gui-zhu-gan decoction (LGZG), a classic traditional Chinese medicine formula, has been confirmed to be effective in improving steatosis in non-alcoholic fatty liver disease (NAFLD). However, the mechanism under the efficacy remains unclear. Hence, this study was designed to investigate the mechanisms of LGZG on alleviating steatosis.<h4>Methods</h4>Twenty four rats were randomly divided into three groups: normal group, NAFLD group, fed with high fat diet (HFD) and LGZG group (fed with HFD and supplemented with LGZG). After 4 weeks intervention, blood and liver were collected. Liver steatosis was detected by Oil Red O staining, and blood lipids were biochemically determined. Whole genome genes were detected by RNA-Seq and the significant different genes were verified","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Jan","modification":"2025-04-19T13:56:01.837Z","creation":"2019-03-26T22:37:00Z"},"accession":"S-EPMC6323852","cross_references":{"pubmed":["30616587"],"doi":["10.1186/s12906-018-2424-1"]}}