{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10(1)"],"submitter":["Hu P"],"pubmed_abstract":["Acidosis is a significant feature of the tumor microenvironment in glioma, and it is closely related to multiple biological functions of cancer stem cells. Here, we found that the self-renewal ability, the mitochondrial activity and ATP production were elevated in stem cell-like glioma cells (SLCs) under acidic microenvironment, which promoted and maintained the stemness of SLCs. Under acidosis, 25-hydroxy vitamin D<sub>3</sub>-24-hydroxylase (CYP24A1) was upregulated and catalyzed the fast degradation of 1α,25(OH)<sub>2</sub>D<sub>3</sub>. We further revealed that the active form of vitamin D (1α,25(OH)<sub>2</sub>D<sub>3</sub>) could inhibit the expression of stemness markers, attenuate acidosis-induced increase of self-renewal ability and mitochondrial respiration in stem cell-like glio"],"journal":["Cell death & disease"],"pagination":["25"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6328565"],"repository":["biostudies-literature"],"pubmed_title":["Acidosis enhances the self-renewal and mitochondrial respiration of stem cell-like glioma cells through CYP24A1-mediated reduction of vitamin D."],"pmcid":["PMC6328565"],"pubmed_authors":["Peng X","Hu Y","Li D","Han W","Jiang T","Wei Z","Wu F","Yuan J","Li Y","Li S","Qiang B","Wei Q","Qi Y","Yin B","Tian N","Hu P"],"additional_accession":[]},"is_claimable":false,"name":"Acidosis enhances the self-renewal and mitochondrial respiration of stem cell-like glioma cells through CYP24A1-mediated reduction of vitamin D.","description":"Acidosis is a significant feature of the tumor microenvironment in glioma, and it is closely related to multiple biological functions of cancer stem cells. Here, we found that the self-renewal ability, the mitochondrial activity and ATP production were elevated in stem cell-like glioma cells (SLCs) under acidic microenvironment, which promoted and maintained the stemness of SLCs. Under acidosis, 25-hydroxy vitamin D<sub>3</sub>-24-hydroxylase (CYP24A1) was upregulated and catalyzed the fast degradation of 1α,25(OH)<sub>2</sub>D<sub>3</sub>. We further revealed that the active form of vitamin D (1α,25(OH)<sub>2</sub>D<sub>3</sub>) could inhibit the expression of stemness markers, attenuate acidosis-induced increase of self-renewal ability and mitochondrial respiration in stem cell-like glio","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Jan","modification":"2025-04-04T10:13:28.19Z","creation":"2019-03-26T22:36:28Z"},"accession":"S-EPMC6328565","cross_references":{"pubmed":["30631035"],"doi":["10.1038/s41419-018-1242-1"]}}