{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15(1)"],"submitter":["Wang X"],"pubmed_abstract":["MicroRNAs regulate post-transcriptional gene expression via either translational repression or mRNA degradation. They have important roles in both viral infection and host anti-infection processes. We discovered that the miR-375 is significantly upregulated in Newcastle disease virus (NDV)-infected chicken embryonic visceral tissues using a small RNA sequencing approach. Further research revealed that the overexpression of miR-375 markedly decreases the replication of the velogenic NDV F48E9 and the lentogenic NDV La Sota by targeting the M gene of NDV in DF-1 cells. Interestingly, miR-375 has another target, ELAVL4, which regulates chicken fibrocyte cell cycle progression and decreases NDV proliferation. In addition, miR-375 can influence bystander cells by its secretion in culture medium"],"journal":["International journal of biological sciences"],"pagination":["44-57"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6329920"],"repository":["biostudies-literature"],"pubmed_title":["MiR-375 Has Contrasting Effects on Newcastle Disease Virus Growth Depending on the Target Gene."],"pmcid":["PMC6329920"],"pubmed_authors":["Li X","Han Q","Yang Z","Wang C","Jia Y","Lv C","Wang X","Chu Z","Zhang S","Xiao S"],"additional_accession":[]},"is_claimable":false,"name":"MiR-375 Has Contrasting Effects on Newcastle Disease Virus Growth Depending on the Target Gene.","description":"MicroRNAs regulate post-transcriptional gene expression via either translational repression or mRNA degradation. They have important roles in both viral infection and host anti-infection processes. We discovered that the miR-375 is significantly upregulated in Newcastle disease virus (NDV)-infected chicken embryonic visceral tissues using a small RNA sequencing approach. Further research revealed that the overexpression of miR-375 markedly decreases the replication of the velogenic NDV F48E9 and the lentogenic NDV La Sota by targeting the M gene of NDV in DF-1 cells. Interestingly, miR-375 has another target, ELAVL4, which regulates chicken fibrocyte cell cycle progression and decreases NDV proliferation. In addition, miR-375 can influence bystander cells by its secretion in culture medium","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019","modification":"2026-05-06T21:04:19.763Z","creation":"2019-03-26T22:37:53Z"},"accession":"S-EPMC6329920","cross_references":{"pubmed":["30662346"],"doi":["10.7150/ijbs.25106"]}}