{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Qi M"],"funding":["NSF","Iowa Soybean Association","USDA NIFA Hatch project","U.S. Department of Agriculture","ISU Center for Metabolic Biology","Iowa State University","ISU Research Foundation","National Science Foundation"],"pagination":["252-263"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC6330549"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["17(1)"],"pubmed_abstract":["Enhancing the nutritional quality and disease resistance of crops without sacrificing productivity is a key issue for developing varieties that are valuable to farmers and for simultaneously improving food security and sustainability. Expression of the Arabidopsis thaliana species-specific AtQQS (Qua-Quine Starch) orphan gene or its interactor, NF-YC4 (Nuclear Factor Y, subunit C4), has been shown to increase levels of leaf/seed protein without affecting the growth and yield of agronomic species. Here, we demonstrate that overexpression of AtQQS and NF-YC4 in Arabidopsis and soybean enhances resistance/reduces susceptibility to viruses, bacteria, fungi, aphids and soybean cyst nematodes. A series of Arabidopsis mutants in starch metabolism were used to explore the relationships between QQS"],"journal":["Plant biotechnology journal"],"pubmed_title":["QQS orphan gene and its interactor NF-YC4 reduce susceptibility to pathogens and pests."],"pmcid":["PMC6330549"],"funding_grant_id":["3808","MCB‐0951170","MCB-0951170","IOS 1546858"],"pubmed_authors":["Qi M","Hohenstein JD","Nettleton D","Whitham SA","O'Conner S","Zheng W","Li L","Zhao X","Du C","Kandel Y","Tylka GL","MacIntosh GC","Wang Y","Wurtele ES"],"additional_accession":[]},"is_claimable":false,"name":"QQS orphan gene and its interactor NF-YC4 reduce susceptibility to pathogens and pests.","description":"Enhancing the nutritional quality and disease resistance of crops without sacrificing productivity is a key issue for developing varieties that are valuable to farmers and for simultaneously improving food security and sustainability. Expression of the Arabidopsis thaliana species-specific AtQQS (Qua-Quine Starch) orphan gene or its interactor, NF-YC4 (Nuclear Factor Y, subunit C4), has been shown to increase levels of leaf/seed protein without affecting the growth and yield of agronomic species. Here, we demonstrate that overexpression of AtQQS and NF-YC4 in Arabidopsis and soybean enhances resistance/reduces susceptibility to viruses, bacteria, fungi, aphids and soybean cyst nematodes. A series of Arabidopsis mutants in starch metabolism were used to explore the relationships between QQS","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Jan","modification":"2026-04-30T16:25:11.907Z","creation":"2019-03-26T22:37:58Z"},"accession":"S-EPMC6330549","cross_references":{"pubmed":["29878511"],"doi":["10.1111/pbi.12961"]}}